Islet cell transplantation is a promising option for the restoration of normal glucose
homeostasis in patients with type 1 diabetes. Because graft volume is a crucial issue in islet …

The purification step is one of the most important and difficult procedures in islet isolation for
pancreatic islet transplantation. We previously reported that a purification method using …

Islet transplantation (IT) has recently been shown to be a promising alternative to pancreas
transplantation for reversing diabetes. IT requires the isolation of the islets from the …

In type I diabetes mellitus, islet transplantation provides a moment-to-moment fine regulation
of insulin. Success rates vary widely, however, necessitating suitable methods to monitor …

Aims: Human pancreas preservation for islet transplantation holds additional challenges
and considerations compared to whole pancreas transplantation. The purpose of this study …

Islet purification is one of the most important steps of islet isolation for pancreatic islet
transplantation. The most common method of islet purification is density gradient …

Background. Although the outcome of islet transplantation has improved, there remains a
major obstacle in isolating viable islets from prolonged preserved pancreas. We previously …

Background Islet transplantation is a viable treatment alternative for a select group of
patients with type 1 diabetes. However, variables unique to the donor pancreas, such as …

Low yield and insufficient purity limit the transplantation of human islets of Langerhans. In
the rat, a new technique to isolate the islets of Langerhans was developed by intraarterial …

Aims/hypothesis Large quantities of pure viable donor islets are necessary for clinical
transplantation. At present, low yields and low viability of pancreatic islets after …