Hazen and Smith An Antiatherosclerotic Signaling Cascade 949 low-circulating systemic
levels. 16 The limited bioavailability of ingested anthocyanins has raised questions of a …

Rationale: We and others have demonstrated that anthocyanins have antiatherogenic
capability. Because intact anthocyanins are absorbed very poorly, the low level of circulating …

ATP-binding cassette transporter A1 (ABCA1) plays a crucial role in reverse cholesterol
transport and exhibits anti-atherosclerosis effects. Some microRNAs (miRs) regulate ABCA1 …

Objective—The ATP-binding cassette transporter A1 (ABCA1) is a major regulator of
macrophage cholesterol efflux and protects cells from excess intracellular cholesterol …

Rationale Macrophage accumulation of cholesterol leads to foam cell formation which is a
major pathological event of atherosclerosis. Recent studies have shown that microRNA …

Rationale: Inhibition of miR-33 reduces atherosclerotic plaque burden, but miR-33 deficient
mice are predisposed to the development of obesity and metabolic dysfunction. The …

Hypoxia is a crucial factor contributing to maintenance of atherosclerotic lesions. The ability
of ABCA1 to stimulate the efflux of cholesterol from cells in the periphery, particularly foam …

Atherosclerosis is caused by cholesterol accumulation within arteries. The intima is where
atherosclerotic plaque accumulates and where lipid-laden foam cells reside. Intimal foam …

Background MicroRNAs play key roles in regulating cholesterol homeostasis. Here, we
investigated the role of microRNA-101 (miR-101) in regulating ATP-binding cassette …

Rationale Macrophage cholesterol homeostasis maintenance is the result of a balance
between influx, endogenous synthesis, esterification/hydrolysis and efflux. Excessive …