Blockade of 5-HT2 receptors suppresses rate of torque development and motor unit discharge rate during rapid contractions
BI Goodlich, SA Horan… - Journal of …, 2022 - journals.physiology.org
Serotonin (5-HT) is a neuromodulator that is critical for regulating the excitability of spinal
motoneurons and the generation of muscle torque. However, the role of 5-HT in modulating …
motoneurons and the generation of muscle torque. However, the role of 5-HT in modulating …
Human corticospinal-motoneuronal output is reduced with 5-HT2 receptor antagonism
JR Thorstensen, JL Taylor… - Journal of …, 2021 - journals.physiology.org
Animal models indicate that serotonin (5-HT) release onto motoneurons facilitates motor
output, particularly during strong motor activities. However, evidence for 5-HT effects during …
output, particularly during strong motor activities. However, evidence for 5-HT effects during …
Enhanced availability of serotonin increases activation of unfatigued muscle but exacerbates central fatigue during prolonged sustained contractions
JJ Kavanagh, AJ McFarland… - The Journal of …, 2019 - Wiley Online Library
Key points Animal preparations have revealed that moderate synaptic release of serotonin
(5‐HT) onto motoneurones enhances motor activity via activation of 5‐HT2 receptors …
(5‐HT) onto motoneurones enhances motor activity via activation of 5‐HT2 receptors …
Excitatory drive to spinal motoneurones is necessary for serotonin to modulate motoneurone excitability via 5‐HT2 receptors in humans
TT Henderson, JL Taylor… - European Journal of …, 2024 - Wiley Online Library
Serotonin modulates corticospinal excitability, motoneurone firing rates and contractile
strength via 5‐HT2 receptors. However, the effects of these receptors on cortical and …
strength via 5‐HT2 receptors. However, the effects of these receptors on cortical and …
Enhanced availability of serotonin limits muscle activation during high-intensity, but not low-intensity, fatiguing contractions
TT Henderson, JL Taylor… - Journal of …, 2022 - journals.physiology.org
Serotonin (5-HT) modulates motoneuron excitability during muscle contractions, where the
release of 5-HT in the central nervous system (CNS) is linked to the intensity of physical …
release of 5-HT in the central nervous system (CNS) is linked to the intensity of physical …
Enhanced serotonin availability amplifies fatigue perception and modulates the TMS‐induced silent period during sustained low‐intensity elbow flexions
Key points During maximal effort contractions, intense serotonin release via the raphe‐
spinal pathway spills over from the somato‐dendritic compartment to activate inhibitory 5 …
spinal pathway spills over from the somato‐dendritic compartment to activate inhibitory 5 …
Physiological tremor is suppressed and force steadiness is enhanced with increased availability of serotonin regardless of muscle fatigue
TT Henderson, JR Thorstensen… - Journal of …, 2022 - journals.physiology.org
Although there is evidence that 5-HT acts as an excitatory neuromodulator to enhance
maximal force generation, it is largely unknown how 5-HT activity influences the ability to …
maximal force generation, it is largely unknown how 5-HT activity influences the ability to …
Blockade of 5‐HT2 receptors suppresses motor unit firing and estimates of persistent inward currents during voluntary muscle contraction in humans
Serotonergic neuromodulation contributes to enhanced voluntary muscle activation.
However, it is not known how the likely motoneurone receptor candidate (5‐HT2) influences …
However, it is not known how the likely motoneurone receptor candidate (5‐HT2) influences …
5‐HT2 receptor antagonism reduces human motoneuron output to antidromic activation but not to stimulation of corticospinal axons
JR Thorstensen, JL Taylor… - European Journal of …, 2022 - Wiley Online Library
The intrinsic electrical properties of motoneurons strongly affect motoneuron excitability to
fast‐acting excitatory ionotropic inputs. Serotonin (5‐HT) is a neurochemical that alters the …
fast‐acting excitatory ionotropic inputs. Serotonin (5‐HT) is a neurochemical that alters the …
Voluntary activation of muscle in humans: does serotonergic neuromodulation matter?
JJ Kavanagh, JL Taylor - The Journal of physiology, 2022 - Wiley Online Library
Ionotropic inputs to motoneurones have the capacity to depolarise and hyperpolarise the
motoneurone, whereas neuromodulatory inputs control the state of excitability of the …
motoneurone, whereas neuromodulatory inputs control the state of excitability of the …