Yolk sac macrophage progenitors traffic to the embryo during defined stages of development
C Stremmel, R Schuchert, F Wagner, R Thaler… - Nature …, 2018 - nature.com
Tissue macrophages in many adult organs originate from yolk sac (YS) progenitors, which
invade the developing embryo and persist by means of local self-renewal. However, the …
invade the developing embryo and persist by means of local self-renewal. However, the …
Tissue-resident macrophages originate from yolk sac-derived erythro-myeloid progenitors
EG Perdiguero, K Klapproth, C Schulz… - Experimental …, 2015 - exphem.org
Macrophages are phagocytic cells that orchestrate homeostatic and innate immune
functions, via the scavenging of cells, debris, and pathogens, and the production of …
functions, via the scavenging of cells, debris, and pathogens, and the production of …
Deciphering human macrophage development at single-cell resolution
Macrophages are the first cells of the nascent immune system to emerge during embryonic
development. In mice, embryonic macrophages infiltrate developing organs, where they …
development. In mice, embryonic macrophages infiltrate developing organs, where they …
Transcriptome‐based profiling of yolk sac‐derived macrophages reveals a role for Irf8 in macrophage maturation
N Hagemeyer, K Kierdorf, K Frenzel, J Xue… - The EMBO …, 2016 - embopress.org
Recent studies have shown that tissue macrophages (MΦ) arise from embryonic progenitors
of the yolk sac (YS) and fetal liver and colonize tissues before birth. Further studies have …
of the yolk sac (YS) and fetal liver and colonize tissues before birth. Further studies have …
The origin of tissue-resident macrophages: when an erythro-myeloid progenitor is an erythro-myeloid progenitor
EG Perdiguero, K Klapproth, C Schulz, K Busch… - Immunity, 2015 - cell.com
Sheng, Ruedl, and Karjalainen published in Immunity (Sheng et al., 2015) a fatemapping
model where the expression of Cre recombinase was inducible in Kit-expressing cells (Kit …
model where the expression of Cre recombinase was inducible in Kit-expressing cells (Kit …
Yolk sac macrophages, fetal liver, and adult monocytes can colonize an empty niche and develop into functional tissue-resident macrophages
Tissue-resident macrophages can derive from yolk sac macrophages (YS-Macs), fetal liver
monocytes (FL-MOs), or adult bone-marrow monocytes (BM-MOs). The relative capacity of …
monocytes (FL-MOs), or adult bone-marrow monocytes (BM-MOs). The relative capacity of …
Three pathways to mature macrophages in the early mouse yolk sac
JY Bertrand, A Jalil, M Klaine, S Jung, A Cumano… - Blood, 2005 - ashpublications.org
The existence of macrophages (Mφ) of yolk-sac (YS) origin has been reported in all
vertebrate models. However, the nature of their precursors and pathways of differentiation …
vertebrate models. However, the nature of their precursors and pathways of differentiation …
Ontogeny of tissue-resident macrophages
The origin of tissue-resident macrophages, crucial for homeostasis and immunity, has
remained controversial until recently. Originally described as part of the mononuclear …
remained controversial until recently. Originally described as part of the mononuclear …
Tissue-resident macrophages originate from yolk-sac-derived erythro-myeloid progenitors
E Gomez Perdiguero, K Klapproth, C Schulz, K Busch… - Nature, 2015 - nature.com
Most haematopoietic cells renew from adult haematopoietic stem cells (HSCs),,, however,
macrophages in adult tissues can self-maintain independently of HSCs,,,. Progenitors with …
macrophages in adult tissues can self-maintain independently of HSCs,,,. Progenitors with …
An immune cell atlas reveals the dynamics of human macrophage specification during prenatal development
Macrophages are heterogeneous and play critical roles in development and disease, but
their diversity, function, and specification remain inadequately understood during human …
their diversity, function, and specification remain inadequately understood during human …