Yolk sac macrophage progenitors traffic to the embryo during defined stages of development

C Stremmel, R Schuchert, F Wagner, R Thaler… - Nature …, 2018 - nature.com
Tissue macrophages in many adult organs originate from yolk sac (YS) progenitors, which
invade the developing embryo and persist by means of local self-renewal. However, the …

Tissue-resident macrophages originate from yolk sac-derived erythro-myeloid progenitors

EG Perdiguero, K Klapproth, C Schulz… - Experimental …, 2015 - exphem.org
Macrophages are phagocytic cells that orchestrate homeostatic and innate immune
functions, via the scavenging of cells, debris, and pathogens, and the production of …

Deciphering human macrophage development at single-cell resolution

Z Bian, Y Gong, T Huang, CZW Lee, L Bian, Z Bai… - Nature, 2020 - nature.com
Macrophages are the first cells of the nascent immune system to emerge during embryonic
development. In mice, embryonic macrophages infiltrate developing organs, where they …

Transcriptome‐based profiling of yolk sac‐derived macrophages reveals a role for Irf8 in macrophage maturation

N Hagemeyer, K Kierdorf, K Frenzel, J Xue… - The EMBO …, 2016 - embopress.org
Recent studies have shown that tissue macrophages (MΦ) arise from embryonic progenitors
of the yolk sac (YS) and fetal liver and colonize tissues before birth. Further studies have …

The origin of tissue-resident macrophages: when an erythro-myeloid progenitor is an erythro-myeloid progenitor

EG Perdiguero, K Klapproth, C Schulz, K Busch… - Immunity, 2015 - cell.com
Sheng, Ruedl, and Karjalainen published in Immunity (Sheng et al., 2015) a fatemapping
model where the expression of Cre recombinase was inducible in Kit-expressing cells (Kit …

Yolk sac macrophages, fetal liver, and adult monocytes can colonize an empty niche and develop into functional tissue-resident macrophages

L van de Laar, W Saelens, S De Prijck, L Martens… - Immunity, 2016 - cell.com
Tissue-resident macrophages can derive from yolk sac macrophages (YS-Macs), fetal liver
monocytes (FL-MOs), or adult bone-marrow monocytes (BM-MOs). The relative capacity of …

Three pathways to mature macrophages in the early mouse yolk sac

JY Bertrand, A Jalil, M Klaine, S Jung, A Cumano… - Blood, 2005 - ashpublications.org
The existence of macrophages (Mφ) of yolk-sac (YS) origin has been reported in all
vertebrate models. However, the nature of their precursors and pathways of differentiation …

Ontogeny of tissue-resident macrophages

G Hoeffel, F Ginhoux - Frontiers in immunology, 2015 - frontiersin.org
The origin of tissue-resident macrophages, crucial for homeostasis and immunity, has
remained controversial until recently. Originally described as part of the mononuclear …

Tissue-resident macrophages originate from yolk-sac-derived erythro-myeloid progenitors

E Gomez Perdiguero, K Klapproth, C Schulz, K Busch… - Nature, 2015 - nature.com
Most haematopoietic cells renew from adult haematopoietic stem cells (HSCs),,, however,
macrophages in adult tissues can self-maintain independently of HSCs,,,. Progenitors with …

An immune cell atlas reveals the dynamics of human macrophage specification during prenatal development

Z Wang, Z Wu, H Wang, R Feng, G Wang, M Li… - Cell, 2023 - cell.com
Macrophages are heterogeneous and play critical roles in development and disease, but
their diversity, function, and specification remain inadequately understood during human …