Nanoparticles: oral delivery for protein and peptide drugs

S Cao, S Xu, H Wang, Y Ling, J Dong, R Xia, X Sun - Aaps Pharmscitech, 2019 - Springer
Protein and peptide drugs have many advantages, such as high bioactivity and specificity,
strong solubility, and low toxicity. Therefore, the strategies for improving the bioavailability of …

Polymeric nano-and microparticles for the oral delivery of peptides and peptidomimetics

E Allémann, JC Leroux, R Gurny - Advanced drug delivery reviews, 1998 - Elsevier
Due to recent advances, numerous bioactive peptides are now available in large quantities.
Administering these substances by the oral route appears as a formidable challenge due to …

Nanoparticles for oral delivery: targeted nanoparticles with peptidic ligands for oral protein delivery

Y Yun, YW Cho, K Park - Advanced drug delivery reviews, 2013 - Elsevier
As the field of biotechnology has advanced, oral protein delivery has also made significant
progress. Oral delivery is the most common method of drug administration with high levels of …

Recent advances in protein and peptide drug delivery: a special emphasis on polymeric nanoparticles

A Patel, M Patel, X Yang, AK Mitra - Protein and peptide letters, 2014 - ingentaconnect.com
Proteins and peptides are widely indicated in many diseased states. Parenteral route is the
most commonly em-ployed method of administration for therapeutic proteins and peptides …

Nanoencapsulation II. Biomedical applications and current status of peptide and protein nanoparticulate delivery systems

CP Reis, RJ Neufeld, AJ Ribeiro, F Veiga - … : Nanotechnology, Biology and …, 2006 - Elsevier
The concept of polymeric nanoparticles for the design of new drug delivery systems
emerged a few years ago, and recent rapid advances in nanotechnology have offered a …

Recent insights in the use of nanocarriers for the oral delivery of bioactive proteins and peptides

P Batista, PM Castro, AR Madureira, B Sarmento… - Peptides, 2018 - Elsevier
Bioactive proteins and peptides have been used with either prophylactic or therapeutic
purposes, presenting inherent advantages as high specificity and biocompatibility …

How to design the surface of peptide-loaded nanoparticles for efficient oral bioavailability?

H Malhaire, JC Gimel, E Roger, JP Benoît… - Advanced drug delivery …, 2016 - Elsevier
The oral administration of proteins is a current challenge to be faced in the field of
therapeutics. There is currently much interest in nanocarriers since they can enhance oral …

Oral delivery of therapeutic proteins and peptides: a review on recent developments

S Gupta, A Jain, M Chakraborty, JK Sahni, J Ali… - Drug …, 2013 - Taylor & Francis
Advent of recombinant technology in protein synthesis has given birth to a new range of
biopharmaceuticals. These therapeutic peptides and proteins are now emerging as an …

Design of nanoparticles composed of graft copolymers for oral peptide delivery

S Sakuma, M Hayashi, M Akashi - Advanced drug delivery reviews, 2001 - Elsevier
The development of a dosage form that improves the absorption of peptide and protein
drugs via the gastrointestinal tract is one of the greatest challenges in the pharmaceutical …

Peptide and protein delivery using new drug delivery systems

A Jain, A Jain, A Gulbake, S Shilpi… - Critical Reviews™ in …, 2013 - dl.begellhouse.com
Pharmaceutical and biotechnological research sorts protein drug delivery systems by
importance based on their various therapeutic applications. The effective and potent action …