Sleep, which is an essential part of human life, is modulated by neurotransmitter systems,
including gamma-aminobutyric acid (GABA) and dopamine signaling. However, the …

Although melatonin is necessary for circadian regulation of sleep, the mechanisms
underlying this effect of melatonin are still unclear. In the present study, we showed that …

Melatonin (MLT) is an important circadian signal for sleep regulation, but the neural
circuitries underlying the sleep-promoting effects of MLT are poorly understood. The …

The aim of this study was to evaluate, in comparison with melatonin (MLT), the effects of a
novel 2-melatonin derivative, having a 2-trifluoromethyl group (MLTD) on the sleep–wake …

Stress may trigger sleep disorders and are also risk factors for depression. The study
explored the melatonin-related mechanisms of stress-associated sleep disorders on a …

Sleep/wake alterations are predominant in neurological and neuropsychiatric disorders
involving dopamine dysfunction. Unfortunately, specific, mechanisms‐based therapies for …

Melatonin (MLT) is widely used to treat sleep disorders although the underlying mechanism
is still elusive. In mice, using wheel‐running detection, we found that exogenous MLT could …

The pharmacological potential of targeting selectively melatonin MT1 or MT2 receptors has
not yet been exploited in medicine. Research using selective MT1/MT2 receptor ligands and …

Sleep deprivation (SD) is commonplace in today's fast-paced society. SD is a severe public
health problem globally since it may cause cognitive decline and even neurodegenerative …

Parkinson's disease (PD) is one of the most common neurodegenerative diseases. There is
a wide range of sleep disturbances in patients with PD, such as insomnia and rapid eye …