This review is dedicated to chronopharmacology and chronotherapeutics of hypertension
interventions. The aim of chronopharmacology is to determine the most suitable time for …

Medical chronobiology deals with the way body's rhythm influences a person's health and
disease states. To match body rhythms, deliberate alteration of drug concentration is done to …

Physiological functions of cardiovascular system (CVS) are exhibiting circadian patterns
regulated by complex system of endogenous factors. Preserving this rhythmicity is important …

Hypertension occurs in over 90% of all patients with cardiovascular disease (CVD) in the
United States and it is a major risk factor for end-organ damage, CVD and death. In the …

Over the last few years, we have gained increasing knowledge regarding the regulatory
roles of clock genes for nearly all physiological functions in single cells, plants, animals and …

Cardiac circadian rhythms are an important regulator of body functions, including cardiac
activities and blood pressure. Disturbance of circadian rhythm is known to trigger and …

Chronopharmaceutical drug delivery systems are gaining a lot of interest as they deliver the
drug at the right site of action, right time and right amount, as per the pathophysiological …

The rise in age-adjusted mortality rates from hypertension and hypertensive diseases over
the last several years suggests that hypertension is one of the main risk factors for heart …

For more than 100 years, investigations have established that nearly all bodily processes
fluctuate in predictable rhythms. Chronobiology is the study of these biological rhythms and …

The cardiovascular system is highly organised in time; blood pressure (BP), heart rate (HR),
peripheral resistance, pressure and the release/activity of vasodilating hormones all display …