Rational Design and Characterization of Nitric Oxide Biosensors in E. coli Nissle 1917 and Mini SimCells

XJ Chen, B Wang, IP Thompson… - ACS Synthetic …, 2021 - ACS Publications
Nitric oxide (NO) is an important disease biomarker found in many chronic inflammatory
diseases and cancers. A well-characterized nitric sensing system is useful to aid the rapid …

Discovery of a Novel Nitric Oxide Binding Protein and Nitric-Oxide-Responsive Signaling Pathway in Pseudomonas aeruginosa

S Hossain, EM Boon - ACS infectious diseases, 2017 - ACS Publications
Nitric oxide (NO) is a radical diatomic gas molecule that, at low concentrations, plays
important signaling roles in both eukaryotes and bacteria. In recent years, it has become …

There's NO stopping NsrR, a global regulator of the bacterial NO stress response

NP Tucker, NE Le Brun, R Dixon, MI Hutchings - Trends in microbiology, 2010 - cell.com
Nitric oxide (NO) is a toxic, free radical gas with diverse biological roles in eukaryotes and
bacteria, being involved in signalling, vasodilation, blood clotting and immunity and as an …

[HTML][HTML] Genetic programming by nitric oxide-sensing gene switch system in tumor-targeting bacteria

Y Qin, SH You, Y Zhang, A Venu, Y Hong, JJ Min - Biosensors, 2023 - mdpi.com
Recent progress in synthetic biology has enabled bacteria to respond to specific disease
signals to perform diagnostic and/or therapeutic tasks. Salmonella enterica subsp. enterica …

A designed whole-cell biosensor for live diagnosis of gut inflammation through nitrate sensing

SG Woo, SJ Moon, SK Kim, TH Kim, HS Lim… - Biosensors and …, 2020 - Elsevier
Microbes reprogrammed using advanced genetic circuits are envisaged as emerging living
diagnostics for a wide range of diseases and play key roles in regulating gut microbiota to …

Sensing nitric oxide in cells: Historical technologies and future outlook

B Almeida, KE Rogers, OK Nag, JB Delehanty - ACS sensors, 2021 - ACS Publications
Nitric oxide (NO) is a critical cell signaling molecule with important roles in both normal
cellular physiology and pathology. Over the past 20 years, multiple sensing modalities have …

[HTML][HTML] Bacterial nitric-oxide synthases operate without a dedicated redox partner

I Gusarov, M Starodubtseva, ZQ Wang… - Journal of Biological …, 2008 - ASBMB
Bacterial nitric-oxide (NO) synthases (bNOSs) are smaller than their mammalian
counterparts. They lack an essential reductase domain that supplies electrons during NO …

Bacterial heme-based sensors of nitric oxide

E WilliamsDominique - Antioxidants & redox signaling, 2018 - el.liebertpub.com
Significance: The molecule nitric oxide (NO) has been shown to regulate behaviors in
bacteria, including biofilm formation. NO detection and signaling in bacteria is typically …

An introduction to nitric oxide sensing and response in bacteria

AM Stern, J Zhu - Advances in applied microbiology, 2014 - Elsevier
Nitric oxide (NO) is a radical gas that has been intensively studied for its role as a
bacteriostatic agent. NO reacts in complex ways with biological molecules, especially metal …

Mechanism of transcriptional regulation by the Escherichia coli nitric oxide sensor NorR

NP Tucker, B D'autréaux, S Spiro… - Biochemical Society …, 2006 - portlandpress.com
Nitric oxide (NO) is a highly reactive water-soluble gas encountered by bacteria
endogenously as an intermediate of denitrification and exogenously as one of the radical …