Cannabidiol induces systemic analgesia through activation of the PI3Kγ/nNOS/NO/KATP signaling pathway in neuropathic mice. A KATP channel S-nitrosylation …

DL de Almeida, RCM Ferreira, FC Fonseca… - Nitric Oxide, 2024 - Elsevier
Background Cannabidiol (CBD) is the second most abundant pharmacologically active
component present in Cannabis sp. Unlike Δ-9-tetrahydrocannabinol (THC), it has no …

[HTML][HTML] Insights on cannabidiol's antiallodynic and anxiolytic mechanisms of action in a model of neuropathic pain

M Schott - Pain Reports, 2019 - journals.lww.com
Recent studies have shown that cannabidiol (CBD) could have a great therapeutic potential
for treating disorders such as chronic pain and anxiety. In the target article, the authors …

Peripherally injected canabidiol reduces neuropathic pain in mice: Role of the 5-HT1A and TRPV1 receptors

DD Aguiar, C da Costa Oliveira, FCS Fonseca… - Biochemical and …, 2023 - Elsevier
Cannabidiol (CBD) is the most abundant non-psychoactive component found in plants of the
genus Cannabis. Its analgesic effect for the treatment of neuropathy has been widely …

Cannabidiol modulates chronic neuropathic pain aversion behavior by attenuation of neuroinflammation markers and neuronal activity in the corticolimbic circuit in …

GK Silva-Cardoso, W Lazarini-Lopes, EO Primini… - Behavioural Brain …, 2023 - Elsevier
Chronic neuropathic pain (CNP) is a vast world health problem often associated with the
somatosensory domain. This conceptualization is problematic because, unlike most other …

Can cannabidiol have an analgesic effect?

B Kulesza, M Mazurek, J Kurzepa - Fundamental & Clinical …, 2024 - Wiley Online Library
Background Cannabis, more commonly known as marijuana or hemp, has been used for
centuries to treat various conditions. Cannabis contains two main components cannabidiol …

Cannabidiol effectively reverses mechanical and thermal allodynia, hyperalgesia, and anxious behaviors in a neuropathic pain model: Possible role of CB1 and …

GK Silva-Cardoso, W Lazarini-Lopes, JE Hallak… - …, 2021 - Elsevier
The incidence of chronic pain is high in the general population and it is closely related to
anxiety disorders, which promote negative effects on the quality of life. The cannabinoid …

Synergistic effect of cannabidiol and transcutaneous electrical nerve stimulation on neuropathic and inflammatory pain in mice

I Malta, G Netto, R Dos Santos, F Veras, G Galdino - NeuroReport, 2023 - journals.lww.com
Objectives Pain is the most common cause of seeking healthcare and the leading cause of
disability worldwide. Although cannabidiol and transcutaneous electrical nerve stimulation …

Cannabidiol enhances the antinociceptive effects of morphine and attenuates opioid-induced tolerance in the chronic constriction injury model

CHA Jesus, MV Ferreira, AT Gasparin, ES Rosa… - Behavioural Brain …, 2022 - Elsevier
Neuropathic pain (NP) is a complex health problem that includes sensorial manifestations
such as evoked and ongoing pain. Cannabidiol (CBD) has shown potential in the treatment …

Cannabidiol attenuates hypersensitivity and oxidative stress after traumatic spinal cord injury in rats

V Baron-Flores, A Diaz-Ruiz, J Manzanares, C Rios… - Neuroscience …, 2022 - Elsevier
Neuropathic pain (NP) arises as a direct consequence of traumatic spinal cord injury (SCI),
which leads to devastating consequences for people suffering from this condition since no …

[HTML][HTML] Cannabidiol attenuates mechanical allodynia in streptozotocin-induced diabetic rats via serotonergic system activation through 5-HT1A receptors

CHA Jesus, DDB Redivo, AT Gasparin, BB Sotomaior… - Brain research, 2019 - Elsevier
Most diabetic patients describe moderate to severe pain symptoms whose pharmacological
treatment is palliative and poorly effective. Cannabidiol (CBD) has shown promising results …