[HTML][HTML] Cannabidiol attenuates mechanical allodynia in streptozotocin-induced diabetic rats via serotonergic system activation through 5-HT1A receptors
CHA Jesus, DDB Redivo, AT Gasparin, BB Sotomaior… - Brain research, 2019 - Elsevier
Most diabetic patients describe moderate to severe pain symptoms whose pharmacological
treatment is palliative and poorly effective. Cannabidiol (CBD) has shown promising results …
treatment is palliative and poorly effective. Cannabidiol (CBD) has shown promising results …
The non-psychoactive cannabis constituent cannabidiol is an orally effective therapeutic agent in rat chronic inflammatory and neuropathic pain
B Costa, AE Trovato, F Comelli, G Giagnoni… - European journal of …, 2007 - Elsevier
Cannabidiol, the major psycho-inactive component of cannabis, has substantial anti-
inflammatory and immunomodulatory effects. This study investigated its therapeutic potential …
inflammatory and immunomodulatory effects. This study investigated its therapeutic potential …
Cannabidiol for pain treatment: focus on pharmacology and mechanism of action
J Mlost, M Bryk, K Starowicz - International journal of molecular sciences, 2020 - mdpi.com
Cannabis has a long history of medical use. Although there are many cannabinoids present
in cannabis, Δ9tetrahydrocannabinol (Δ9-THC) and cannabidiol (CBD) are the two …
in cannabis, Δ9tetrahydrocannabinol (Δ9-THC) and cannabidiol (CBD) are the two …
Combined non-psychoactive Cannabis components cannabidiol and β-caryophyllene reduce chronic pain via CB1 interaction in a rat spinal cord injury model
A Eeswara, A Pacheco-Spiewak, S Jergova, J Sagen - PloS one, 2023 - journals.plos.org
The most frequently reported use of medical marijuana is for pain relief. However, its
psychoactive component Δ9-tetrahydrocannabinol (THC) causes significant side effects …
psychoactive component Δ9-tetrahydrocannabinol (THC) causes significant side effects …
[HTML][HTML] " IUPHAR review-Preclinical Models of Neuropathic Pain: Evaluating Multifunctional Properties of Natural Cannabinoid Receptors Ligands
K Benamar - Pharmacological Research, 2023 - Elsevier
Neuropathic pain remains prevalent and challenging to manage and is often comorbid with
depression and anxiety. The new approach that simultaneously targets neuropathic pain …
depression and anxiety. The new approach that simultaneously targets neuropathic pain …
[HTML][HTML] The antinociceptive activity and mechanism of action of cannabigerol
Y Wen, Z Wang, R Zhang, Y Zhu, G Lin, R Li… - Biomedicine & …, 2023 - Elsevier
Cannabis has been used for centuries to treat pain. The antinociceptive activity of
tetrahydrocannabinol (THC) or cannabidiol (CBD) has been widely studied. However, the …
tetrahydrocannabinol (THC) or cannabidiol (CBD) has been widely studied. However, the …
Cannabidiol inhibition of murine primary nociceptors: Tight binding to slow inactivated states of Nav1. 8 channels
HXB Zhang, BP Bean - Journal of Neuroscience, 2021 - Soc Neuroscience
The nonpsychoactive phytocannabinoid cannabidiol (CBD) has been shown to have
analgesic effects in animal studies but little is known about its mechanism of action. We …
analgesic effects in animal studies but little is known about its mechanism of action. We …
Cannabis constituent synergy in a mouse neuropathic pain model
SL Casey, N Atwal, CW Vaughan - Pain, 2017 - journals.lww.com
Cannabis and its psychoactive constituent D9-tetrahydrocannabinol (THC) have efficacy
against neuropathic pain, however, this is hampered by their side effects. It has been …
against neuropathic pain, however, this is hampered by their side effects. It has been …
Pain response to cannabidiol in induced acute nociceptive pain, allodynia, and hyperalgesia by using a model mimicking acute pain in healthy adults in a randomized …
T Schneider, L Zurbriggen, M Dieterle, E Mauermann… - Pain, 2022 - journals.lww.com
Preclinical studies have demonstrated the analgesic potential of cannabidiol (CBD). Those
suggesting an effect on pain-processing receptors have brought CBD back into focus. This …
suggesting an effect on pain-processing receptors have brought CBD back into focus. This …
Cannabidiol modulates serotonergic transmission and reverses both allodynia and anxiety-like behavior in a model of neuropathic pain
Clinical studies indicate that cannabidiol (CBD), the primary nonaddictive component of
cannabis that interacts with the serotonin (5-HT) 1A receptor, may possess analgesic and …
cannabis that interacts with the serotonin (5-HT) 1A receptor, may possess analgesic and …