The weight of evidence gathered from studies in humans with hereditary polycystic kidney
disease (PKD) 1 and PKD2 disorders, as well as from experimental animal models …

Autosomal dominant polycystic kidney disease (ADPKD) progresses to end-stage renal
insufficiency before the age of 73 in approximately 48% of affected individuals. Why the …

Autosomal-dominant polycystic kidney disease (ADPKD), largely neglected for several
decades, has emerged in recent years as the renal disease most likely to be understood …

Renal cysts, which arise from renal tubules, can be seen in a variety of hereditary and
nonhereditary entities. Common mechanisms associated with renal cyst formation include …

Polycystic kidney disease (PKD) is a multiorgan disorder resulting in fluid-filled cyst
formation in the kidneys and other systems. The replacement of kidney parenchyma with an …

Autosomal dominant polycystic kidney disease (ADPKD) is a common genetic disorder
affecting 1 in 1,000 people in the general population and accounts for up to 10% of all …

Autosomal dominant polycystic kidney disease is a genetic disorder associated with
substantial variability in its natural course within and between affected families …

Background and objectives: Potential therapeutic interventions are being developed for
autosomal dominant polycystic kidney disease (ADPKD). A pivotal question will be when to …

Polycystic kidney diseases are inherited renal disorders due mainly to mutations in genes
that regulate the development and function of cells that line renal tubules. This review …

Autosomal dominant polycystic kidney disease (ADPKD) is caused by mutations in PKD1 or
PKD2, which encode polycystin-1 and polycystin-2, respectively. Rodent models are …