The role of doublesex in the evolution of exaggerated horns in the Japanese rhinoceros beetle

Y Ito, A Harigai, M Nakata, T Hosoya, K Araya… - EMBO …, 2013 - embopress.org
Male‐specific exaggerated horns are an evolutionary novelty and have diverged rapidly via
intrasexual selection. Here, we investigated the function of the conserved sex‐determination …

Precise staging of beetle horn formation in Trypoxylus dichotomus reveals the pleiotropic roles of doublesex depending on the spatiotemporal developmental …

S Morita, T Ando, A Maeno, T Mizutani, M Mase… - PLoS …, 2019 - journals.plos.org
Many scarab beetles have sexually dimorphic exaggerated horns that are an evolutionary
novelty. Since the shape, number, size, and location of horns are highly diverged within …

Diversification of doublesex function underlies morph-, sex-, and species-specific development of beetle horns

T Kijimoto, AP Moczek… - Proceedings of the …, 2012 - National Acad Sciences
Sex-specific trait expression is frequently associated with highly variable, condition-
dependent expression within sexes and rapid divergence among closely related species …

Asymmetric interactions between doublesex and tissue- and sex-specific target genes mediate sexual dimorphism in beetles

CC Ledón-Rettig, EE Zattara, AP Moczek - Nature Communications, 2017 - nature.com
Sexual dimorphisms fuel significant intraspecific variation and evolutionary diversification.
Yet the developmental-genetic mechanisms underlying sex-specific development remain …

Evolutionary transition of doublesex regulation from sex-specific splicing to male-specific transcription in termites

S Miyazaki, K Fujiwara, K Kai, Y Masuoka, H Gotoh… - Scientific reports, 2021 - nature.com
The sex determination gene doublesex (dsx) encodes a transcription factor with two
domains, oligomerization domain 1 (OD1) and OD2, and is present throughout insects. Sex …

Beetle horns are regulated by the Hox gene, Sex combs reduced, in a species‐ and sex‐specific manner

BR Wasik, DJ Rose, AP Moczek - Evolution & development, 2010 - Wiley Online Library
Discovering the mechanisms that underlie the origin of novel features represents a major
frontier in developmental and evolutionary biology. Here we begin to characterize the role of …

Sex determination in beetles: Production of all male progeny by Parental RNAi knockdown of transformer

JN Shukla, SR Palli - Scientific reports, 2012 - nature.com
Sex in insects is determined by a cascade of regulators ultimately controlling sex-specific
splicing of a transcription factor, Doublesex (Dsx). We recently identified homolog of dsx in …

Identification and functional analyses of sex determination genes in the sexually dimorphic stag beetle Cyclommatus metallifer

H Gotoh, RA Zinna, I Warren, M DeNieu, T Niimi… - BMC genomics, 2016 - Springer
Background Genes in the sex determination pathway are important regulators of sexually
dimorphic animal traits, including the elaborate and exaggerated male ornaments and …

Doublesex target genes in the red flour beetle, Tribolium castaneum

JN Shukla, SR Palli - Scientific reports, 2012 - nature.com
Sex determination cascade in insects terminates with the production of sex-specific protein,
Doublesex (Dsx). We identified the dsx homolog (Tcdsx) in Tribolium castaneum. The pre …

Evolutionary history of sexual differentiation mechanism in insects

Y Chikami, M Okuno, A Toyoda, T Itoh… - Molecular Biology and …, 2022 - academic.oup.com
Alternative splicing underpins functional diversity in proteins and the complexity and
diversity of eukaryotes. An example is the doublesex gene, the key transcriptional factor in …