[HTML][HTML] Structural role for DNA Ligase IV in promoting the fidelity of non-homologous end joining
BM Stinson, SM Carney, JC Walter… - Nature Communications, 2024 - nature.com
Nonhomologous end joining (NHEJ), the primary pathway of vertebrate DNA double-strand-
break (DSB) repair, directly re-ligates broken DNA ends. Damaged DSB ends that cannot be …
break (DSB) repair, directly re-ligates broken DNA ends. Damaged DSB ends that cannot be …
Repair of DNA double-strand breaks by the nonhomologous end joining pathway
BM Stinson, JJ Loparo - Annual review of biochemistry, 2021 - annualreviews.org
DNA double-strand breaks pose a serious threat to genome stability. In vertebrates, these
breaks are predominantly repaired by nonhomologous end joining (NHEJ), which pairs DNA …
breaks are predominantly repaired by nonhomologous end joining (NHEJ), which pairs DNA …
[HTML][HTML] Holding it together: DNA end synapsis during non-homologous end joining
JJ Loparo - DNA repair, 2023 - Elsevier
DNA double strand breaks (DSBs) are common lesions whose misrepair are drivers of
oncogenic transformations. The non-homologous end joining (NHEJ) pathway repairs the …
oncogenic transformations. The non-homologous end joining (NHEJ) pathway repairs the …
[HTML][HTML] A mechanism to minimize errors during non-homologous end joining
Enzymatic processing of DNA underlies all DNA repair, yet inappropriate DNA processing
must be avoided. In vertebrates, double-strand breaks are repaired predominantly by non …
must be avoided. In vertebrates, double-strand breaks are repaired predominantly by non …
Single-molecule imaging reveals the kinetics of non-homologous end-joining in living cells
Non-homologous end joining (NHEJ) is the predominant pathway that repairs DNA double-
stranded breaks (DSBs) in vertebrates. However, due to challenges in detecting DSBs in …
stranded breaks (DSBs) in vertebrates. However, due to challenges in detecting DSBs in …
Structure of a NHEJ polymerase-mediated DNA synaptic complex
NC Brissett, RS Pitcher, R Juarez, AJ Picher, AJ Green… - Science, 2007 - science.org
Nonhomologous end joining (NHEJ) is a critical DNA double-strand break (DSB) repair
pathway required to maintain genome stability. Many prokaryotes possess a minimalist …
pathway required to maintain genome stability. Many prokaryotes possess a minimalist …
Two distinct long-range synaptic complexes promote different aspects of end processing prior to repair of DNA breaks by non-homologous end joining
Non-homologous end joining is the major double-strand break repair (DSBR) pathway in
mammals. DNA-PK is the hub and organizer of multiple steps in non-homologous end …
mammals. DNA-PK is the hub and organizer of multiple steps in non-homologous end …
[HTML][HTML] Two-stage synapsis of DNA ends during non-homologous end joining
Repair of DNA double-strand breaks (DSBs) is essential for genomic stability. The most
common DSB repair mechanism in human cells, non-homologous end joining (NHEJ) …
common DSB repair mechanism in human cells, non-homologous end joining (NHEJ) …
[HTML][HTML] DNA ligase IV guides end-processing choice during nonhomologous end joining
Nonhomologous end joining (NHEJ) must adapt to diverse end structures during repair of
chromosome breaks. Here, we investigate the mechanistic basis for this flexibility. DNA ends …
chromosome breaks. Here, we investigate the mechanistic basis for this flexibility. DNA ends …
Catalytically inactive DNA ligase IV promotes DNA repair in living cells
NJ Goff, M Brenière, CJ Buehl, AJ de Melo… - Nucleic acids …, 2022 - academic.oup.com
DNA double strand breaks (DSBs) are induced by external genotoxic agents (ionizing
radiation or genotoxins) or by internal processes (recombination intermediates in …
radiation or genotoxins) or by internal processes (recombination intermediates in …