[HTML][HTML] Structural role for DNA Ligase IV in promoting the fidelity of non-homologous end joining

BM Stinson, SM Carney, JC Walter… - Nature Communications, 2024 - nature.com
Nonhomologous end joining (NHEJ), the primary pathway of vertebrate DNA double-strand-
break (DSB) repair, directly re-ligates broken DNA ends. Damaged DSB ends that cannot be …

Repair of DNA double-strand breaks by the nonhomologous end joining pathway

BM Stinson, JJ Loparo - Annual review of biochemistry, 2021 - annualreviews.org
DNA double-strand breaks pose a serious threat to genome stability. In vertebrates, these
breaks are predominantly repaired by nonhomologous end joining (NHEJ), which pairs DNA …

[HTML][HTML] Holding it together: DNA end synapsis during non-homologous end joining

JJ Loparo - DNA repair, 2023 - Elsevier
DNA double strand breaks (DSBs) are common lesions whose misrepair are drivers of
oncogenic transformations. The non-homologous end joining (NHEJ) pathway repairs the …

[HTML][HTML] A mechanism to minimize errors during non-homologous end joining

BM Stinson, AT Moreno, JC Walter, JJ Loparo - Molecular cell, 2020 - cell.com
Enzymatic processing of DNA underlies all DNA repair, yet inappropriate DNA processing
must be avoided. In vertebrates, double-strand breaks are repaired predominantly by non …

Single-molecule imaging reveals the kinetics of non-homologous end-joining in living cells

M Mikhova, NJ Goff, T Janovič, JR Heyza, K Meek… - BioRxIV, 2023 - biorxiv.org
Non-homologous end joining (NHEJ) is the predominant pathway that repairs DNA double-
stranded breaks (DSBs) in vertebrates. However, due to challenges in detecting DSBs in …

Structure of a NHEJ polymerase-mediated DNA synaptic complex

NC Brissett, RS Pitcher, R Juarez, AJ Picher, AJ Green… - Science, 2007 - science.org
Nonhomologous end joining (NHEJ) is a critical DNA double-strand break (DSB) repair
pathway required to maintain genome stability. Many prokaryotes possess a minimalist …

Two distinct long-range synaptic complexes promote different aspects of end processing prior to repair of DNA breaks by non-homologous end joining

CJ Buehl, NJ Goff, SW Hardwick, M Gellert, TL Blundell… - Molecular cell, 2023 - cell.com
Non-homologous end joining is the major double-strand break repair (DSBR) pathway in
mammals. DNA-PK is the hub and organizer of multiple steps in non-homologous end …

[HTML][HTML] Two-stage synapsis of DNA ends during non-homologous end joining

TGW Graham, JC Walter, JJ Loparo - Molecular cell, 2016 - cell.com
Repair of DNA double-strand breaks (DSBs) is essential for genomic stability. The most
common DSB repair mechanism in human cells, non-homologous end joining (NHEJ) …

[HTML][HTML] DNA ligase IV guides end-processing choice during nonhomologous end joining

MP Conlin, DA Reid, GW Small, HH Chang… - Cell reports, 2017 - cell.com
Nonhomologous end joining (NHEJ) must adapt to diverse end structures during repair of
chromosome breaks. Here, we investigate the mechanistic basis for this flexibility. DNA ends …

Catalytically inactive DNA ligase IV promotes DNA repair in living cells

NJ Goff, M Brenière, CJ Buehl, AJ de Melo… - Nucleic acids …, 2022 - academic.oup.com
DNA double strand breaks (DSBs) are induced by external genotoxic agents (ionizing
radiation or genotoxins) or by internal processes (recombination intermediates in …