Estrogenic impact on cardiac ischemic/reperfusion injury

S Sivasinprasasn, K Shinlapawittayatorn… - Journal of …, 2016 - Springer
The increase in cardiovascular disease and metabolic syndrome incidence following the
onset of menopause has highlighted the role of estrogen as a cardiometabolic protective …

Estrogen-mediated protection in myocardial ischemia-reperfusion injury

EA Booth, BR Lucchesi - Cardiovascular toxicology, 2008 - Springer
Before menopause, a woman has a relatively low risk for developing cardiovascular
disease. After menopause, however, the risk increases nearly twofold and cardiovascular …

Protection from myocardial reperfusion injury by acute administration of 17β-estradiol

JA Delyani, T Murohara, TO Nossuli… - Journal of molecular and …, 1996 - Elsevier
Although several studies have demonstrated that chronic exposure to estrogen appears to
be cardioprotective, acute circulatory effects of estrogen are largely unknown. Therefore, we …

Unravelling the cardioprotective mechanism of action of estrogens

JA Moolman - Cardiovascular research, 2006 - academic.oup.com
Cardiovascular diseases are the major cause of morbidity and mortality in the developed
world, and are increasing in significance in the developing world. Elucidation of the …

Postischemic infusion of 17-β-estradiol protects myocardial function and viability

AM Terrell, PR Crisostomo, TA Markel, M Wang… - Journal of Surgical …, 2008 - Elsevier
BACKGROUND: Females demonstrate improved cardiac recovery after
ischemia/reperfusion injury compared with males. Attenuation of myocardial dysfunction with …

Gender-based differences in mechanisms of protection in myocardial ischemia–reperfusion injury

E Murphy, C Steenbergen - Cardiovascular research, 2007 - academic.oup.com
Pre-menopausal women have reduced risk for cardiovascular disease, and cardiovascular
disease rises after menopause. Studies in animal models have also suggested that females …

Cardioprotection in females: a role for nitric oxide and altered gene expression

E Murphy, C Steenbergen - Heart failure reviews, 2007 - Springer
A number of epidemiological and animal studies have suggested a cardioprotective role for
estrogen. This review will focus on the cardioprotective role of estrogen in ischemia …

Estrogen diminishes postischemic hydroxyl radical production

NA McHugh, GF Merrill… - American Journal of …, 1998 - journals.physiology.org
Reperfusion of blood flow to an ischemic myocardium is imperative to survival; ironically, it
may also manifest several pathophysiological conditions. The most important of these are …

Age-related differences in cardiac ischemia–reperfusion injury: effects of estrogen deficiency

DH Korzick, TS Lancaster - Pflügers Archiv-European Journal of …, 2013 - Springer
Despite conflicting evidence for the efficacy of hormone replacement therapy in
cardioprotection of postmenopausal women, numerous studies have demonstrated …

Sex‐based differences in cardiac ischaemic injury and protection: therapeutic implications

B Ostadal, P Ostadal - British journal of pharmacology, 2014 - Wiley Online Library
Ischaemic heart disease (IHD) is the most frequent cause of mortality among men and
women. Many epidemiological studies have demonstrated that premenopausal women …