Cryptococcus neoformans is the leading cause of fungal meningitis in humans. Production
of a polysaccharide capsule is a key virulence property for the fungus and capsule synthesis …

The level of available iron in the mammalian host is extremely low, and pathogenic microbes
must compete with host proteins such as transferrin for iron. Iron regulation of gene …

Iron availability is a key regulator of virulence factor elaboration in Cryptococcus
neoformans, the causative agent of fungal meningoencephalitis in HIV/AIDS patients. In …

The acquisition of iron from mammalian hosts is an important aspect of infection because
microbes must compete with the host for this nutrient and iron perception often regulates …

The fungal pathogen Cryptococcus neoformans is a major cause of illness in
immunocompromised individuals such as AIDS patients. The ability of the fungus to acquire …

Vertebrate hosts actively sequester iron, and fungal and other pathogens must therefore
adapt to a severe limitation in iron availability to cause disease. Recent studies reveal that …

Iron acquisition is critical for virulence of the human pathogenic fungus Cryptococcus
neoformans. The cryptococcal transcript for the extracellular mannoprotein Cig1 is highly …

The mechanisms by which pathogens sense and transport iron are important during
infection, because of the low availability of free iron in the mammalian host. Iron is a key …

Iron acquisition is a critical aspect of the virulence of many pathogenic microbes, and iron
limitation is an important defense mechanism for mammalian hosts. We are examining …

The acquisition of iron and the maintenance of iron homeostasis are important aspects of
virulence for the pathogenic fungus Cryptococcus neoformans. In this study, we …