Prevention of Alzheimer's disease: Omega-3 fatty acid and phenolic anti-oxidant interventions

GM Cole, GP Lim, F Yang, B Teter, A Begum, Q Ma… - Neurobiology of …, 2005 - Elsevier
Alzheimer's disease (AD) and cardiovascular disease (CVD) are syndromes of aging that
share analogous lesions and risk factors, involving lipoproteins, oxidative damage and …

Docosahexaenoic acid protects from amyloid and dendritic pathology in an Alzheimer's disease mouse model

GM Cole, SA Frautschy - Nutrition and health, 2006 - journals.sagepub.com
Genetic data argues that Alzheimer's disease (AD) can be initiated by aggregates of a 42
amino acid beta amyloid peptide (Aβ42). The Aβ aggregates, notably small oligomer …

Dietary fatty acids and the aging brain

GM Cole, QL Ma, SA Frautschy - Nutrition reviews, 2010 - academic.oup.com
Aging contributes to physiological decline and vulnerability to disease. In the brain, even
with minimal neuronal loss, aging increases oxidative damage, inflammation, demyelination …

Omega-3 fatty acids and dementia

GM Cole, QL Ma, SA Frautschy - Prostaglandins, Leukotrienes and …, 2009 - Elsevier
More than a dozen epidemiological studies have reported that reduced levels or intake of
omega-3 fatty acids or fish consumption is associated with increased risk for age-related …

Why pleiotropic interventions are needed for Alzheimer's disease

SA Frautschy, GM Cole - Molecular neurobiology, 2010 - Springer
Alzheimer's disease (AD) involves a complex pathological cascade thought to be initially
triggered by the accumulation of β-amyloid (Aβ) peptide aggregates or aberrant amyloid …

A diet enriched with the omega-3 fatty acid docosahexaenoic acid reduces amyloid burden in an aged Alzheimer mouse model

GP Lim, F Calon, T Morihara, F Yang… - Journal of …, 2005 - Soc Neuroscience
Epidemiological studies suggest that increased intake of the omega-3 (n-3) polyunsaturated
fatty acid (PUFA) docosahexaenoic acid (DHA) is associated with reduced risk of …

Omega‐3 Fatty Acids in Early Prevention of Inflammatory Neurodegenerative Disease: A Focus on Alzheimer's Disease

J Thomas, CJ Thomas, J Radcliffe… - BioMed research …, 2015 - Wiley Online Library
Alzheimer's disease (AD) is the leading cause of dementia and the most common
neurodegenerative disease in the elderly. Furthermore, AD has provided the most positive …

Neuroprotective action of omega-3 polyunsaturated fatty acids against neurodegenerative diseases: evidence from animal studies

F Calon, G Cole - Prostaglandins, Leukotrienes and Essential Fatty Acids, 2007 - Elsevier
Studies in animals clearly show that oral intake of docosahexaenoic acid (DHA) can alter
brain DHA concentrations and thereby modify brain functions. This provides us with an …

Omega-3 fatty acids: potential role in the management of early Alzheimer's disease

GA Jicha, WR Markesbery - Clinical interventions in aging, 2010 - Taylor & Francis
Omega-3 fatty acids are essential for brain growth and development. They play an important
role throughout life, as critical modulators of neuronal function and regulation of oxidative …

Alzheimer's disease, amnestic mild cognitive impairment, and age-associated memory impairment: current understanding and progress toward integrative prevention.

PM Kidd - Alternative Medicine Review, 2008 - search.ebscohost.com
Alzheimer's disease (AD) is the most common form of dementia. AD initially targets memory
and progressively destroys the mind. The brain atrophies as the neocortex suffers neuronal …