Neuroprotective capabilities of TSA against cerebral ischemia/reperfusion injury via PI3K/Akt signaling pathway in rats

XH Ma, Q Gao, Z Jia, ZW Zhang - International Journal of …, 2015 - Taylor & Francis
Background: Hundreds of previous studies demonstrated the cytoprotective effect of
trichostatin-A (TSA), a kind of histone deacetylases inhibitors (HDACIs), against cerebral …

PI3K/Akt pathway contributes to neuroprotective effect of Tongxinluo against focal cerebral ischemia and reperfusion injury in rats

ZH Yu, M Cai, J Xiang, ZN Zhang, JS Zhang… - Journal of …, 2016 - Elsevier
Ethnopharmacological relevance Tongxinluo (TXL), a compound prescription, is formulated
according to the collateral disease doctrine of traditional Chinese medicine, and is widely …

[HTML][HTML] Neuroprotective effects of DAHP and Triptolide in focal cerebral ischemia via apoptosis inhibition and PI3K/Akt/mTOR pathway activation

W Li, Y Yang, Z Hu, S Ling, M Fang - Frontiers in neuroanatomy, 2015 - frontiersin.org
Triptolide (TP), one of the major active components of the traditional Chinese herb
Tripterygium wilfordii Hook F, and 2, 4-diamino-6-hydroxypyrimidine (DAHP), an inhibitor of …

[HTML][HTML] Effects of Txk‑mediated activation of NF‑κB signaling pathway on neurological deficit and oxidative stress after ischemia‑reperfusion in rats

QL Xu, J Wu - Molecular Medicine Reports, 2021 - spandidos-publications.com
Ischemic stroke is an extremely mortal cerebrovascular disease, and neuroinflammation and
oxidative stress emerge as important traits of ischemic stroke. However, as an inflammation …

[PDF][PDF] Sodium butyrate relieves cerebral ischemia-reperfusion injury in mice by inhibiting JNK/STAT pathway.

RX Wang, S Li, X Sui - European Review for Medical & …, 2019 - researchgate.net
OBJECTIVE: The aim of this study was to investigate whether sodium butyrate (NaB)
attenuated cerebral ischemia-reperfusion injury (IRI) in mice by inhibiting JNK/STAT …

Neuroprotective effects of Tongxinluo on focal cerebral ischemia and reperfusion injury in rats associated with the activation of the MEK1/2/ERK1/2/p90RSK signaling …

Z Yu, M Cai, X Li, J Zhang, T Wu, F Yang, W Zhu… - Brain Research, 2018 - Elsevier
Ischemic stroke brings a huge family and social burden. Although the reperfusion of
ischemic cerebral tissue is the most important way to rescue ischemic stroke, ischemia …

Cerebroprotective effects of red ginseng extract pretreatment against ischemia-induced oxidative stress and apoptosis

SY Cheon, KJ Cho, JE Lee, HW Kim… - International Journal …, 2013 - Taylor & Francis
Panax ginseng CA Meyer has been traditionally used as a medicinal plant and has
beneficial effects due to pharmacological properties. Although ginseng is thought to be …

[HTML][HTML] Neuroprotective effect of Danhong injection on cerebral ischemia-reperfusion injury in rats by activation of the PI3K-Akt pathway

C Feng, H Wan, Y Zhang, L Yu, C Shao, Y He… - Frontiers in …, 2020 - frontiersin.org
Many traditional Chinese medicines, including Danhong injection (DHI), can be used to treat
cerebral ischemia-reperfusion injury and have neuroprotective effects on the brain; however …

[HTML][HTML] Herbal compatibility of ginseng and rhubarb exerts synergistic neuroprotection in cerebral ischemia/reperfusion injury of rats

WT Yang, Y Wang, YH Shi, H Fu, Z Xu, QQ Xu… - Frontiers in …, 2019 - frontiersin.org
Objective Ischemic stroke is a complex multifactorial disease caused by interactions among
polygenetic, environmental, and lifestyle factors with limited effective treatments. Multi-herbal …

Trichostatin A enhances OGD-astrocyte viability by inhibiting inflammatory reaction mediated by NF-κB

F Niu, X Zhang, L Chang, J Wu, Y Yu, J Chen… - Brain research bulletin, 2009 - Elsevier
In this study we investigate the protective effects of Trichostatin A (TSA) on astrocyte injury
after oxygen–glucose deprivation (OGD) and further explore its possible protective …