In mammalian oocytes, cyclic AMP‐dependent protein kinase (PKA) is responsible for
maintaining meiotic arrest. We examined the role of the predominant regulatory subunit, RIα …

In the mammalian oocyte, the cAMP-dependent protein kinase (PKA) has critical functions in
the maintenance of meiotic arrest and oocyte maturation. Because PKA is spatially …

Reinitiation of meiosis in meiotically competent, fully grown mammalian oocytes is governed
by a fall in intraoocyte cAMP concentrations and the subsequent inactivation of protein …

Substantial evidence has indicated that cAMP-dependent protein kinase (protein kinase A
orPKA) plays a critical role in maintaining meiotic prophase arrest in vertebrate oocytes …

Meiosis in oocytes is initiated during fetal life, arrested around birth and resumed after
puberty. Meiotic arrest is controlled by a cAMP-dependent protein kinase (PKA)-mediated …

Vertebrate oocytes are arrested in G 2 phase of the cell cycle at the prophase border of
meiosis I. Progesterone treatment of Xenopus oocytes releases the G 2 block and promotes …

Oocytes from LTXBO mice exhibit a delayed entry into anaphase I and frequently enter
interphase after the first meiotic division. This unique oocyte model was used to test the …

Progesterone induces G2-arrested Xenopus oocytes to develop into fertilizable eggs in a
process called meiotic maturation. Protein kinase A (PKA), the cAMP-dependent protein …

Oocyte activation is an important process triggered by fertilization that initiates embryonic
development. However, parthenogenetic activation can occur either spontaneously or with …

We report the results of experiments which support the hypothesis that, in mouse oocytes, a
decrease in intraoocyte cyclic AMP (cAMP) initiates meiotic maturation; oocytes …