Peptide-based strategies for enhanced cell uptake, transcellular transport, and circulation: Mechanisms and challenges
Peptides are emerging as a new tool in drug and gene delivery. Peptide-drug conjugates
and peptide-modified drug delivery systems provide new opportunities to avoid macrophage …
and peptide-modified drug delivery systems provide new opportunities to avoid macrophage …
Peptides as drug delivery vehicles across biological barriers
Peptides are small biological molecules that are attractive in drug delivery and materials
engineering for applications including therapeutics, molecular building blocks and cell …
engineering for applications including therapeutics, molecular building blocks and cell …
Peptide-based vectors: A biomolecular engineering strategy for gene delivery
S Urandur, MO Sullivan - Annual Review of Chemical and …, 2023 - annualreviews.org
From the first clinical trial by Dr. WF Anderson to the most recent US Food and Drug
Administration–approved Luxturna (Spark Therapeutics, 2017) and Zolgensma (Novartis …
Administration–approved Luxturna (Spark Therapeutics, 2017) and Zolgensma (Novartis …
Gene delivery by peptide-assisted transport
RK Thapa, MO Sullivan - Current opinion in biomedical engineering, 2018 - Elsevier
The diverse amino acid chemistries and secondary structures in peptides provide
'minimalist'mimics of motifs in proteins and offer many ideal properties for targeted delivery …
'minimalist'mimics of motifs in proteins and offer many ideal properties for targeted delivery …
Cell-penetrating peptides transport therapeutics into cells
JD Ramsey, NH Flynn - Pharmacology & therapeutics, 2015 - Elsevier
Nearly 30 years ago, certain small, relatively nontoxic peptides were discovered to be
capable of traversing the cell membrane. These cell-penetrating peptides, as they are now …
capable of traversing the cell membrane. These cell-penetrating peptides, as they are now …
[HTML][HTML] Recent innovations in peptide based targeted drug delivery to cancer cells
Targeted delivery of chemotherapeutics and diagnostic agents conjugated to carrier ligands
has made significant progress in recent years, both in regards to the structural design of the …
has made significant progress in recent years, both in regards to the structural design of the …
[HTML][HTML] Patient-centric design for peptide delivery: Trends in routes of administration and advancement in drug delivery technologies
AN Ganesh, C Heusser, S Garad… - Medicine in Drug …, 2021 - Elsevier
Utilizing peptides as therapeutic agents is considered an attractive approach for the
treatment of various diseases due to their high binding and selectivity to novel drug targets …
treatment of various diseases due to their high binding and selectivity to novel drug targets …
Recent in vivo advances in cell-penetrating peptide-assisted drug delivery
Introduction: Delivery of macromolecular drugs is an important field in medical research.
However, macromolecules are usually unable to cross the cell membrane without the …
However, macromolecules are usually unable to cross the cell membrane without the …
Therapeutic potential of cell-penetrating peptides
L Vasconcelos, K Pärn, Ü Langel - Therapeutic delivery, 2013 - Future Science
The ability of cell-penetrating peptides to cross plasma membranes has been used for
various applications, including the delivery of bioactive molecules to inhibit disease …
various applications, including the delivery of bioactive molecules to inhibit disease …
Peptide‐mediated targeted drug delivery
S Majumdar, TJ Siahaan - Medicinal research reviews, 2012 - Wiley Online Library
Targeted drug delivery to specific group of cells offers an attractive strategy to minimize the
undesirable side effects and achieve the therapeutic effect with a lower dose. Both linear …
undesirable side effects and achieve the therapeutic effect with a lower dose. Both linear …