Peptide-based strategies for enhanced cell uptake, transcellular transport, and circulation: Mechanisms and challenges

A Komin, LM Russell, KA Hristova… - Advanced drug delivery …, 2017 - Elsevier
Peptides are emerging as a new tool in drug and gene delivery. Peptide-drug conjugates
and peptide-modified drug delivery systems provide new opportunities to avoid macrophage …

Peptides as drug delivery vehicles across biological barriers

D Ghosh, X Peng, J Leal, RP Mohanty - Journal of pharmaceutical …, 2018 - Springer
Peptides are small biological molecules that are attractive in drug delivery and materials
engineering for applications including therapeutics, molecular building blocks and cell …

Peptide-based vectors: A biomolecular engineering strategy for gene delivery

S Urandur, MO Sullivan - Annual Review of Chemical and …, 2023 - annualreviews.org
From the first clinical trial by Dr. WF Anderson to the most recent US Food and Drug
Administration–approved Luxturna (Spark Therapeutics, 2017) and Zolgensma (Novartis …

Gene delivery by peptide-assisted transport

RK Thapa, MO Sullivan - Current opinion in biomedical engineering, 2018 - Elsevier
The diverse amino acid chemistries and secondary structures in peptides provide
'minimalist'mimics of motifs in proteins and offer many ideal properties for targeted delivery …

Cell-penetrating peptides transport therapeutics into cells

JD Ramsey, NH Flynn - Pharmacology & therapeutics, 2015 - Elsevier
Nearly 30 years ago, certain small, relatively nontoxic peptides were discovered to be
capable of traversing the cell membrane. These cell-penetrating peptides, as they are now …

[HTML][HTML] Recent innovations in peptide based targeted drug delivery to cancer cells

Y Gilad, M Firer, G Gellerman - Biomedicines, 2016 - mdpi.com
Targeted delivery of chemotherapeutics and diagnostic agents conjugated to carrier ligands
has made significant progress in recent years, both in regards to the structural design of the …

[HTML][HTML] Patient-centric design for peptide delivery: Trends in routes of administration and advancement in drug delivery technologies

AN Ganesh, C Heusser, S Garad… - Medicine in Drug …, 2021 - Elsevier
Utilizing peptides as therapeutic agents is considered an attractive approach for the
treatment of various diseases due to their high binding and selectivity to novel drug targets …

Recent in vivo advances in cell-penetrating peptide-assisted drug delivery

K Kurrikoff, M Gestin, Ü Langel - Expert opinion on drug delivery, 2016 - Taylor & Francis
Introduction: Delivery of macromolecular drugs is an important field in medical research.
However, macromolecules are usually unable to cross the cell membrane without the …

Therapeutic potential of cell-penetrating peptides

L Vasconcelos, K Pärn, Ü Langel - Therapeutic delivery, 2013 - Future Science
The ability of cell-penetrating peptides to cross plasma membranes has been used for
various applications, including the delivery of bioactive molecules to inhibit disease …

Peptide‐mediated targeted drug delivery

S Majumdar, TJ Siahaan - Medicinal research reviews, 2012 - Wiley Online Library
Targeted drug delivery to specific group of cells offers an attractive strategy to minimize the
undesirable side effects and achieve the therapeutic effect with a lower dose. Both linear …