During the last decade, cell-penetrating peptides have been investigated for their ability to
overcome the plasma membrane barrier of mammalian cells for the intracellular or …

Personal medicine aims to provide tailor-made diagnostics and treatments and has been
emerged as a promising but challenging strategy during the last years. This includes the …

The concept of peptides as therapeutic agents has been historically disregarded by the
pharmaceutical industry on account of their susceptibility to degradation, their size and …

The past decades witnessed an increasing interest in peptides as clinical therapeutics.
Rightfully considered as a potential alternative for small molecule therapy, these remarkable …

Unique characteristics, such as nontoxicity and rapid cellular internalization, allow the cell-
penetrating peptides (CPPs) to transport hydrophilic macromolecules into cells, thus …

The ability to direct the import of therapeutic agents into cells and target them to specific
organelles would greatly enhance their functional efficacy. The available spectrum of …

Peptides play an important role in many fields, including immunology, medical diagnostics,
and drug discovery, due to their high specificity and positive safety profile. However, for their …

Introduction Cell-penetrating peptide (CPP) technologies represent an important strategy to
address drug delivery to specific intracellular compartments by covalent conjugation to …

The presence of cell and tissue barriers together with the low biomembrane permeability of
various therapeutics often hampers systemic drug distribution; thus, most of the available …

Drug delivery systems are generally believed to comprise drugs and excipients. A peptide–
drug conjugate is a single molecule that can simultaneously play multiple roles in a drug …