Volutrauma and atelectrauma have been proposed as mechanisms of ventilator-associated
lung injury, but few studies have compared their relative importance in mediating lung injury …

Lung injury due to mechanical ventilation is associated with an impairment of endogenous
surfactant. It is unknown whether this impairment is a consequence of or an active …

Depletion of alveolar macrophages (AM) leads to an increase in endogenous surfactant that
lasts several days beyond the repletion of AM. Furthermore, impairment to the endogenous …

Mechanical ventilation of the lung is an essential but potentially harmful therapeutic
intervention for patients with acute respiratory distress syndrome. The objective of the …

Objective: Volutrauma and atelectrauma promote ventilator-induced lung injury, but their
relative contribution to inflammation in ventilator-induced lung injury is not well established …

During mechanical ventilation, high end-inspiratory lung volume (whether it be because of
large tidal volume (VT) and/or high levels of positive end-expiratory pressure) results in a …

Understanding how the mechanisms of ventilator-induced lung injury (VILI), namely
atelectrauma and volutrauma, contribute to the failure of the blood-gas barrier and …

The present study examined the effects of mechanical ventilation, with or without positive
end-expiratory pressure (PEEP), on the alveolar surfactant system in an animal model of …

Once the critical care community accepted the hypothesis that mechanical ventilation could
damage the lungs in more ways than “barotrauma,” as defined by Macklin and Macklin some …

With proteinaceous-liquid flooding of discrete alveoli, a model of the edema pattern in the
acute respiratory distress syndrome, lung inflation over expands aerated alveoli adjacent to …