Microglial progranulin: involvement in Alzheimer's disease and neurodegenerative diseases
A Mendsaikhan, I Tooyama, DG Walker - Cells, 2019 - mdpi.com
Neurodegenerative diseases such as Alzheimer's disease have proven resistant to new
treatments. The complexity of neurodegenerative disease mechanisms can be highlighted …
treatments. The complexity of neurodegenerative disease mechanisms can be highlighted …
The role of PGRN in Alzheimer's disease
H Jing, MS Tan, JT Yu, L Tan - Molecular neurobiology, 2016 - Springer
Progranulin (PGRN), a multifunctional growth factor expressed in various tissues, is involved
in a diversity of physiologic and pathological processes, including cell proliferation, wound …
in a diversity of physiologic and pathological processes, including cell proliferation, wound …
Progranulin as a therapeutic target in neurodegenerative diseases
Progranulin (PGRN, encoded by the GRN gene) plays a key role in the development,
survival, function, and maintenance of neurons and microglia in the mammalian brain. It …
survival, function, and maintenance of neurons and microglia in the mammalian brain. It …
The lysosomal function of progranulin, a guardian against neurodegeneration
Progranulin (PGRN), encoded by the GRN gene in humans, is a secreted growth factor
implicated in a multitude of processes ranging from regulation of inflammation to wound …
implicated in a multitude of processes ranging from regulation of inflammation to wound …
Progranulin promotes neurite outgrowth and neuronal differentiation by regulating GSK-3β
Progranulin (PGRN) has recently emerged as a key player in a subset of frontotemporal
dementias (FTD). Numerous mutations in the progranulin gene have been identified in …
dementias (FTD). Numerous mutations in the progranulin gene have been identified in …
Progranulin in neurodegenerative dementia
XM Wang, P Zeng, YY Fang, T Zhang… - Journal of …, 2021 - Wiley Online Library
Long‐term or severe lack of protective factors is important in the pathogenesis of
neurodegenerative dementia. Progranulin (PGRN), a neurotrophic factor expressed mainly …
neurodegenerative dementia. Progranulin (PGRN), a neurotrophic factor expressed mainly …
Progranulin: normal function and role in neurodegeneration
JL Eriksen, IRA Mackenzie - Journal of neurochemistry, 2008 - Wiley Online Library
Progranulin (PGRN) is a multifunctional protein that has attracted significant attention in the
neuroscience community following the recent discovery of PGRN mutations in some cases …
neuroscience community following the recent discovery of PGRN mutations in some cases …
Progranulin in frontotemporal lobar degeneration and neuroinflammation
Z Ahmed, IRA Mackenzie, ML Hutton… - Journal of …, 2007 - Springer
Progranulin (PGRN) is a pleiotropic protein that has gained the attention of the neuroscience
community with recent discoveries of mutations in the gene for PGRN that cause …
community with recent discoveries of mutations in the gene for PGRN that cause …
Regulation of progranulin expression in human microglia and proteolysis of progranulin by matrix metalloproteinase-12 (MMP-12)
HS Suh, N Choi, L Tarassishin, SC Lee - PloS one, 2012 - journals.plos.org
Background The essential role of progranulin (PGRN) as a neurotrophic factor has been
demonstrated by the discovery that haploinsufficiency due to GRN gene mutations causes …
demonstrated by the discovery that haploinsufficiency due to GRN gene mutations causes …
Progranulin functions as a neurotrophic factor to regulate neurite outgrowth and enhance neuronal survival
P Van Damme, A Van Hoecke, D Lambrechts… - The Journal of cell …, 2008 - rupress.org
Recently, mutations in the progranulin (PGRN) gene were found to cause familial and
apparently sporadic frontotemporal lobe dementia (FTLD). Moreover, missense changes in …
apparently sporadic frontotemporal lobe dementia (FTLD). Moreover, missense changes in …