Microbes, such as bacteria and viruses, utilize channel proteins that play an important role in
the infection process, and thus are considered virulence factors. With the rise in antibiotic …

Viroporins are small virus-encoded ion channel proteins. Most viroporins are monovalent
selective cation channels, with few showing the ability to conduct divalent cations, like …

Uropathogenic Escherichia coli are the main causal agents of urinary tract infections. Pili are
bacterial surface adhesive organelles that are critical virulence factors in the successful …

Viroporins play a key role in the virus life cycle and have become promising targets for
inhibitory drug and vaccine development. All members of this protein familiy share some …

The chaperone/usher system is one of the best characterized pathways for protein secretion
and assembly of cell surface appendages in Gram-negative bacteria. In particular, this …

Viroporins are a family of small hydrophobic proteins found in many enveloped viruses that
are capable of ion transport. Building upon the ability to inhibit influenza by blocking its …

Viroporins comprise a family of non-structural proteins that play significant and diverse roles
during the replication cycle of many animal viruses. Consequently, they have become …

PapC ushers are outer-membrane proteins enabling assembly and secretion of P pili in
uropathogenic E. coli. Their translocation domain is a large β-barrel occluded by a plug …

Since the discovery that certain small viral membrane proteins, collectively termed as
viroporins, can permeabilize host cellular membranes and also behave as ion channels …

Ion channels are membrane proteins essential for a plethora of cellular functions including
maintaining cell shape, ion homeostasis, cardiac rhythm and action potential in neurons …