Background The emergence of plasmid-mediated tet (X3)/tet (X4) genes is threatening the
role of tigecycline as a last-resort antibiotic to treat clinical infections caused by XDR …

The Lancet Microbe have highlighted the spread of tigecycline resistance mediated by the
RND efflux pump gene cluster tmexCD-toprJ, in clinically important pathogens. 1–3 …

Emergence of tigecycline-resistance tet (X) gene orthologues rendered tigecycline
ineffective as last-resort antibiotic. To understand the potential origin and transmission …

Tigecycline is a glycylcycline antibiotic active against multidrug-resistant bacterial
pathogens. The objectives of our study were to examine the potential of the Tet (A), Tet (K) …

The emergence of the plasmid-mediated high-level tigecycline resistance mechanism Tet
(X) threatens the role of tigecycline as the “last-resort” antibiotic in the treatment of infections …

Tetracycline and its derivative tigecycline are clinical options against Gram‐negative
bacterial infections. The emergence of mobile Tet (X) enzymes that destruct tetracycline …

ABSTRACT A growing number of tet (X)-type tigecycline resistance determinants [tet (X1) to
tet (X5)] constitutes an expanding family of tetracycline-inactivating enzymes, posing a …

Tigecycline is a last-resort antibiotic that is used to treat severe infections caused by
extensively drug-resistant bacteria. tet (X) has been shown to encode a flavin-dependent …

Recently, many TetX variants such as Tet (X3~ 14) were reported to confer resistance to
tigecycline which is a last-resort antibiotic used to treat infections caused by multidrug …

Objectives To elucidate the mechanism of tigecycline resistance in Escherichia coli that is
mediated by the tet (A) variant gene. Methods E. coli strain 573 carried a plasmid-borne tet …