Direct oral anticoagulants—Interference with laboratory tests and mechanism of action

DA Tsakiris - Seminars in hematology, 2014 - Elsevier
Direct oral anticoagulants (DOACs) have been established and already registered for
clinical use on a wide basis in the United States and Europe. Different from the vitamin K …

[HTML][HTML] Update on laboratory testing and hemostasis assessment in patients receiving direct oral anticoagulants (DOACs)

V Perifanis, N Neokleous, DA Tsakiris - Thrombosis Update, 2021 - Elsevier
Direct oral anticoagulants (DOACs) have been established and already registered
worldwide for clinical use. Contrary to vitamin K antagonists, their mode of action is based …

[HTML][HTML] Laboratory monitoring of direct oral anticoagulants (DOACs)

C Dunois - Biomedicines, 2021 - mdpi.com
The introduction of direct oral anticoagulants (DOACs), such as dabigatran, rivaroxaban,
apixaban, edoxaban, and betrixaban, provides safe and effective alternative to previous …

Recent guidelines and recommendations for laboratory assessment of the direct oral anticoagulants (DOACs): is there consensus?

G Lippi, EJ Favaloro - Clinical Chemistry and Laboratory Medicine …, 2015 - degruyter.com
A new generation of antithrombotic agents, which are conventionally known as direct oral
anticoagulants (DOACs), have recently emerged and are continuing to be developed. These …

Clinical judgment when using coagulation tests during direct oral anticoagulant treatment: a concise review

A Di Minno, G Spadarella, D Prisco… - … in thrombosis and …, 2013 - thieme-connect.com
Because their anticoagulant effect is dose predictable, steady, and little influenced by diet
and drugs, laboratory monitoring was deemed unnecessary in trials on venous and arterial …

The laboratory and the new oral anticoagulants

A Tripodi - Clinical chemistry, 2013 - academic.oup.com
BACKGROUND The new oral anticoagulants (NOAs) dabigatran, rivaroxaban, and
apixaban have proved effective and safe when used in clinical trials, without a need to …

Direct oral anticoagulants (DOACs): From the laboratory point of view

S Margetić, S ŠUPRAHA GORETA, I Ćelap… - Acta …, 2022 - hrcak.srce.hr
Sažetak Direct oral anticoagulants (DOACs) represent a new generation of drugs that have
been increasingly used in the prevention and treatment of thromboembolic states. According …

The direct Oral anticoagulants Apixaban, rivaroxaban, and edoxaban

KA DeHaas - American Society for Clinical Laboratory Science, 2017 - clsjournal.ascls.org
Traditionally, anticoagulant therapy has been conducted through the administration of
vitamin K antagonists (VKAs) and parenteral alternatives. Direct Oral Anticoagulants …

[HTML][HTML] Laboratory testing in patients treated with direct oral anticoagulants: a practical guide for clinicians

J Douxfils, W Ageno, CM Samama, S Lessire… - Journal of Thrombosis …, 2018 - Elsevier
Click to hear Dr Baglin's perspective on the role of the laboratory in treatment with new oral
anticoagulants Summary One of the key benefits of the direct oral anticoagulants (DOACs) is …

Direct oral anticoagulants: new drugs and new concepts

JH Levy, AC Spyropoulos, CM Samama… - JACC: Cardiovascular …, 2014 - jacc.org
Direct oral anticoagulants (DOACs) are approved for multiple thromboembolic disorders and
provide advantages over existing agents. As with all anticoagulants, management protocols …