[HTML][HTML] Modeling hemolytic-uremic syndrome: in-depth characterization of distinct murine models reflecting different features of human disease

S Dennhardt, W Pirschel, B Wissuwa, C Daniel… - Frontiers in …, 2018 - frontiersin.org
Diarrhea-positive hemolytic-uremic syndrome (HUS) is a renal disorder that results from
infections with Shiga-toxin (Stx)-producing Escherichia coli. The aim of this study was to …

[HTML][HTML] Cardiovascular impairment in Shiga-toxin-2-induced experimental hemolytic–uremic syndrome: a pilot study

C Neu, B Wissuwa, C Thiemermann… - Frontiers in …, 2023 - frontiersin.org
Introduction Hemolytic–uremic syndrome (HUS) can occur as a systemic complication of
infection with Shiga toxin (Stx)-producing Escherichia coli (STEC). Most well-known aspects …

A murine model of HUS: Shiga toxin with lipopolysaccharide mimics the renal damage and physiologic response of human disease

TR Keepers, MA Psotka, LK Gross… - Journal of the American …, 2006 - journals.lww.com
Hemolytic uremic syndrome (HUS), which is caused by Shiga toxin–producing Escherichia
coli infection, is the leading cause of acute renal failure in children. At present, there is no …

Gene expression profile and injury sites in mice treated with Shiga toxin 2 and lipopolysaccharide as a Shiga toxin-associated hemolytic uremic syndrome model

Y Kume, H Go, R Maeda, K Suyama… - Physiological …, 2022 - journals.physiology.org
Shiga toxin 2 (Stx2) and lipopolysaccharide (LPS) contribute to the development of
hemolytic uremic syndrome (HUS). Mouse models of HUS induced by LPS/Stx2 have been …

[HTML][HTML] Experimental in vivo models of bacterial Shiga toxin-associated hemolytic uremic syndrome

YJ Jeong, SK Park, SJ Yoon, YJ Park, MS Lee - 2018 - jmb.or.kr
Shiga toxins (Stxs) are the main virulence factors expressed by the pathogenic Stx-
producing bacteria, namely, Shigella dysenteriae serotype 1 and certain Escherichia coli …

[HTML][HTML] Distinct renal pathology and a chemotactic phenotype after enterohemorrhagic Escherichia coli Shiga toxins in non-human primate models of hemolytic …

DJ Stearns-Kurosawa, SY Oh, RP Cherla… - The American Journal of …, 2013 - Elsevier
Enterohemorrhagic Escherichia coli cause approximately 1.5 million infections globally with
176,000 cases occurring in the United States annually from ingesting contaminated food …

Is immune cell activation the missing link in the pathogenesis of post-diarrhoeal HUS?

RS Heyderman, M Soriani, TR Hirst - Trends in microbiology, 2001 - cell.com
Haemolytic uraemic syndrome (HUS), which is caused by Shiga toxin (Stx)-producing
Escherichia coli, is the commonest cause of acute renal failure in childhood. It is widely …

Mouse model of hemolytic-uremic syndrome caused by endotoxin-free Shiga toxin 2 (Stx2) and protection from lethal outcome by anti-Stx2 antibody

KAD Sauter, AR Melton-Celsa, K Larkin… - Infection and …, 2008 - Am Soc Microbiol
Hemolytic-uremic syndrome (HUS) results from infection by Shiga toxin (Stx)-producing
Escherichia coli and is the most common cause of acute renal failure in children. We have …

Mouse model for hemolytic uremic syndrome induced by outer membrane vesicles of Escherichia coli O157:H7

SH Kim, YH Lee, SH Lee, SR Lee… - FEMS Immunology & …, 2011 - academic.oup.com
Hemolytic uremic syndrome (HUS) is characterized by acute renal failure in children and is
typically complicated with thrombocytopenia and hemolytic anemia. Although mouse models …

[HTML][HTML] LPS-primed CD11b+ leukocytes serve as an effective carrier of Shiga toxin 2 to cause hemolytic uremic syndrome in mice

S Niu, J Paluszynski, Z Bian, L Shi, K Kidder, Y Liu - Scientific Reports, 2018 - nature.com
Shiga toxin (Stx)-induced hemolytic uremic syndrome (HUS) is a life-threatening
complication associated with Stx-producing Escherichia coli infection. One critical barrier of …