Liver fibrosis is the result of a deregulated wound healing process characterized by the
excessive deposition of extracellular matrix. Hepatic stellate cells (HSCs), which are …

Liver fibrosis is characterized by the persistent deposition of extracellular matrix components
by hepatic stellate cell (HSC)-derived myofibroblasts. It is the histological manifestation of …

Background and Aims Activated hepatocytes are hypothesized to be a major source of
signals that drive cirrhosis, but the biochemical pathways that convert hepatocytes into such …

Background & Aims Chronic failure of mechanisms that promote effective regeneration of
dead hepatocytes causes replacement of functional hepatic parenchyma with fibrous scar …

Liver is highly regenerative as it can restore its function and size even after 70% partial
hepatectomy. During liver regeneration, the mechanical and chemical environment of liver is …

Severe fibrosis often leads to significant mortality as a result of liver failure and cirrhosis.
Recent evidence arising in the Journal of Hepatology etc. shed light on the role of the …

Primary sclerosing cholangitis (PSC) represents a chronic liver disease characterized by
poor prognosis and lacking causal treatment options. Yes-associated protein (YAP) …

Mechanobiology is a domain of interdisciplinary research that aims to explore the impact of
physical force, applied externally or internally, on cell and tissue function, including …

Hepatocytes are the primary functional cells of the liver, performing its metabolic,
detoxification, and endocrine functions. Functional hepatocytes are extremely valuable in …

Fibrosis due to extracellular matrix (ECM) secretion from myofibroblasts complicates many
chronic liver diseases causing scarring and organ failure. Integrin-dependent interaction …