Inflammatory role of high salt level in tumor microenvironment
S Amara, V Tiriveedhi - International journal of …, 2017 - spandidos-publications.com
Chronic inflammation is known to play a critical role in cancer development and progression.
High salt is known to mediate several chronic inflammatory diseases including hypertension …
High salt is known to mediate several chronic inflammatory diseases including hypertension …
NFAT5/STAT3 interaction mediates synergism of high salt with IL-17 towards induction of VEGF-A expression in breast cancer cells
S Amara, D Alotaibi, V Tiriveedhi - Oncology letters, 2016 - spandidos-publications.com
Chronic inflammation has been considered an important player in cancer proliferation and
progression. High salt (sodium chloride) levels have been considered a potent inducer of …
progression. High salt (sodium chloride) levels have been considered a potent inducer of …
High salt inhibits tumor growth by enhancing anti-tumor immunity
R Willebrand, I Hamad, L Van Zeebroeck… - Frontiers in …, 2019 - frontiersin.org
Excess salt intake could affect the immune system by shifting the immune cell balance
toward a pro-inflammatory state. Since this shift of the immune balance is thought to be …
toward a pro-inflammatory state. Since this shift of the immune balance is thought to be …
High salt diet may promote progression of breast tumor through eliciting immune response
J Chen, X Liu, H Huang, F Zhang, Y Lu, H Hu - International …, 2020 - Elsevier
Objective Dietary patterns are believed to regulate tumor progression by altering the tumor
microenvironment. Of note, a high salt diet is a risk factor for various diseases. However, the …
microenvironment. Of note, a high salt diet is a risk factor for various diseases. However, the …
Critical role of SIK3 in mediating high salt and IL-17 synergy leading to breast cancer cell proliferation
S Amara, C Majors, B Roy, S Hill, KL Rose, EL Myles… - PloS one, 2017 - journals.plos.org
Chronic inflammation is a well-known precursor for cancer development and proliferation.
We have recently demonstrated that high salt (NaCl) synergizes with sub-effective …
We have recently demonstrated that high salt (NaCl) synergizes with sub-effective …
High-salt diet inhibits tumour growth in mice via regulating myeloid-derived suppressor cell differentiation
W He, J Xu, R Mu, Q Li, D Lv, Z Huang, J Zhang… - Nature …, 2020 - nature.com
High-salt diets are associated with an elevated risk of autoimmune diseases, and immune
dysregulation plays a key role in cancer development. However, the correlation between …
dysregulation plays a key role in cancer development. However, the correlation between …
[HTML][HTML] High salt induces P-glycoprotein mediated treatment resistance in breast cancer cells through store operated calcium influx
D Babaer, S Amara, M Ivy, Y Zhao, PE Lammers… - Oncotarget, 2018 - ncbi.nlm.nih.gov
Recent evidence from our laboratory has demonstrated that high salt (Δ0. 05 M NaCl)
induced inflammatory response and cancer cell proliferation through salt inducible kinase-3 …
induced inflammatory response and cancer cell proliferation through salt inducible kinase-3 …
Acidosis promotes tumorigenesis by activating AKT/NF-κB signaling
L Yang, X Hu, YY Mo - Cancer and Metastasis Reviews, 2019 - Springer
The microenvironment of solid tumors is often acidic due to poor vascular perfusion, regional
hypoxia, and increased glycolytic activity of tumor cells. Although acidosis is harmful to most …
hypoxia, and increased glycolytic activity of tumor cells. Although acidosis is harmful to most …
Sodium as an important regulator of immunometabolism
H Miyauchi, S Geisberger, FC Luft, N Wilck… - …, 2024 - Am Heart Assoc
Salt sensitivity concerns blood pressure alterations after a change in salt intake (sodium
chloride). The heart is a pump, and vessels are tubes; sodium can affect both. A high salt …
chloride). The heart is a pump, and vessels are tubes; sodium can affect both. A high salt …
New insights on the role of sodium in the physiological regulation of blood pressure and development of hypertension
E Polychronopoulou, P Braconnier… - Frontiers in …, 2019 - frontiersin.org
A precise maintenance of sodium and fluid balance is an essential step in the regulation of
blood pressure and alterations of this balance may lead to the development of hypertension …
blood pressure and alterations of this balance may lead to the development of hypertension …
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