We designed a series of experiments and analyses to quantify the contribution of gravity to
pulmonary perfusion heterogeneity. Regional pulmonary perfusion was measured in five …

To explain the changes in pulmonary vascular resistance (PVR) with positive-and negative-
pressure inflation (PPI and NPI, respectively), we studied their effects in isolated canine left …

Redistribution of pulmonary blood flow (PBF) away from edematous regions of the lung is
characteristic of experimental acute lung injury (ALI), helping to preserve ventilation …

Purpose To determine whether the injection rate of contrast agent affects the dynamics of
enhancement of the pulmonary parenchyma on magnetic resonance (MR) pulmonary …

Single-photon emission-computed tomography (SPECT) on intact dogs and humans
suggests that one aspect of regional blood flow in the lung (Qr) is independent of gravity, eg …

We hypothesized that the perfusion heterogeneity in the human, upright lung is determined
by nongravitational more than gravitational factors. Twelve and six subjects were studied …

Isolated cat lungs were perfused with constant blood flow. During control conditions (Pa02,
100 Torr), pulmonary artery pressure increased as the lungs were inflated. Hypoxia (Pa02 …

Purpose In this feasibility study, a phase‐resolved functional lung imaging postprocessing
method for extraction of dynamic perfusion (Q) and ventilation (V) parameters using a …

The aim of this study was to develop a magnetic resonance (MR) sequence capable of
measuring water content and the gravity-dependent gradient in lung density in normal lung …

Although some central aspects of pulmonary function (ventilation and perfusion) are known
to be heterogeneous, the distribution of diffusive gas exchange remains poorly …