Minocycline modulates neuropathic pain behaviour and cortical M1–M2 microglial gene expression in a rat model of depression
There is a paucity of data on the role of microglia and neuroinflammatory processes in the
association between chronic pain and depression. The current study examined the effect of …
association between chronic pain and depression. The current study examined the effect of …
Spinal versus brain microglial and macrophage activation traits determine the differential neuroinflammatory responses and analgesic effect of minocycline in chronic …
Z Li, H Wei, S Piirainen, Z Chen, E Kalso… - Brain, behavior, and …, 2016 - Elsevier
Substantial evidence indicates involvement of microglia/macrophages in chronic
neuropathic pain. However, the temporal-spatial features of microglial/macrophage …
neuropathic pain. However, the temporal-spatial features of microglial/macrophage …
Minocycline prevents the development of neuropathic pain, but not acute pain: possible anti-inflammatory and antioxidant mechanisms
SSV Padi, SK Kulkarni - European journal of pharmacology, 2008 - Elsevier
Glia, particularly astrocytes and microglia, are known to play an important role in central
sensitization and are strongly implicated in the exaggerated pain states. In the present study …
sensitization and are strongly implicated in the exaggerated pain states. In the present study …
Minocycline alleviates depression-like symptoms by rescuing decrease in neurogenesis in dorsal hippocampus via blocking microglia activation/phagocytosis
B Bassett, S Subramaniyam, Y Fan, S Varney… - Brain, behavior, and …, 2021 - Elsevier
Clinical studies examining the potential of anti-inflammatory agents, specifically of
minocycline, as a treatment for depression has shown promising results. However …
minocycline, as a treatment for depression has shown promising results. However …
Intrathecal minocycline attenuates peripheral inflammation‐induced hyperalgesia by inhibiting p38 MAPK in spinal microglia
XY Hua, CI Svensson, T Matsui… - European Journal of …, 2005 - Wiley Online Library
Activation of p38 mitogen‐activated protein kinase (p38) in spinal microglia is implicated in
spinal nociceptive processing. Minocycline, a tetracycline derivative, displays selective …
spinal nociceptive processing. Minocycline, a tetracycline derivative, displays selective …
Systemic administration of minocycline inhibits formalin-induced inflammatory pain in rat
It has been demonstrated that spinal microglial activation is involved in formalin-induced
pain and that minocycline, an inhibitor of microglial activation, attenuate behavioral …
pain and that minocycline, an inhibitor of microglial activation, attenuate behavioral …
Minocycline attenuates mechanical allodynia and proinflammatory cytokine expression in rat models of pain facilitation
Activated glial cells (microglia and astroglia) in the spinal cord play a major role in mediating
enhanced pain states by releasing proinflammatory cytokines and other substances thought …
enhanced pain states by releasing proinflammatory cytokines and other substances thought …
[HTML][HTML] Involvement of pro-and antinociceptive factors in minocycline analgesia in rat neuropathic pain model
E Rojewska, K Popiolek-Barczyk, AM Jurga… - Journal of …, 2014 - Elsevier
In neuropathic pain the repeated minocycline treatment inhibited the mRNA and protein
expression of the microglial markers and metalloproteinase-9 (MMP-9). The minocycline …
expression of the microglial markers and metalloproteinase-9 (MMP-9). The minocycline …
[HTML][HTML] Minocycline attenuates lipopolysaccharide (LPS)-induced neuroinflammation, sickness behavior, and anhedonia
CJ Henry, Y Huang, A Wynne, M Hanke… - Journal of …, 2008 - Springer
Background Activation of the peripheral innate immune system stimulates the secretion of
CNS cytokines that modulate the behavioral symptoms of sickness. Excessive production of …
CNS cytokines that modulate the behavioral symptoms of sickness. Excessive production of …
Minocycline and pentoxifylline attenuate allodynia and hyperalgesia and potentiate the effects of morphine in rat and mouse models of neuropathic pain
J Mika, M Osikowicz, W Makuch… - European journal of …, 2007 - Elsevier
Recent research has shown that microglial cells which are strongly activated in neuropathy
can influence development of allodynia and hyperalgesia. Here we demonstrated that …
can influence development of allodynia and hyperalgesia. Here we demonstrated that …