Rationale Whereas reward-modulatory opioid actions have been intensively studied in
subcortical sites such as the nucleus accumbens (Acb), the role of cortical opioid …

Loss of inhibitory control over appetitively motivated behavior occurs in multiple psychiatric
disorders, including drug abuse, behavioral addictions, and eating disorders with binge …

Opioid neurotransmission has been implicated in psychiatric disorders featuring impaired
control over appetitive motivation, such as addiction and binge-eating disorder. We have …

Mu opioid receptor (MOR) signaling in the nucleus accumbens (NAcc) elicits marked
increases in the consumption of palatable tastants. However, the mechanism and circuitry …

Opioid transmission and dysregulated prefrontal cortex (PFC) activity have both been
implicated in the inhibitory-control deficits associated with addiction and binge-type eating …

There is a long-standing interest in the role of endogenous opioid peptides in feeding
behavior and, in particular, in the modulation of food reward and palatability. Since drugs …

Frontal cortical regions are activated by food-associated stimuli, and this activation appears
to be dysregulated in individuals with eating disorders. Nevertheless, frontal control of basic …

Our previous studies have shown that stimulation of mu-opioid receptors within the nucleus
accumbens preferentially enhances intake of palatable food containing sucrose and fat; …

This study explored potentially dissociable functions of mu-opioid receptor (µ-OR) signaling
across different cortical territories in the control of anticipatory activity directed toward …

Opioid signaling in the nucleus accumbens (NAcc) regulates feeding behavior, having
particularly strong effects on consumption of highly palatable foods. Since macronutrient …