Background The most common cystic fibrosis (CF) manifestation is the progressive chronic
obstructive pulmonary disease caused by deficiency, dysfunction, or absence of the CFTR …

Purpose Chronic obstructive pulmonary disease (COPD) is a multi-factorial disorder caused
by environmental determinants and genetic risk factors. Understanding the genetic …

There has been a recent emphasis on identifying modifier genes that influence the severity
of cystic fibrosis (CF) lung disease. The beta‐2‐adrenergic receptor is expressed on airway …

Background Chronic obstructive pulmonary disease (COPD) is a heterogeneous and
complex disease of which the pathogenesis remains largely unknown. Many factors could …

Background COPD is characterized by a persistent airflow limitation that is not fully
reversible; thus, the reversibility of airflow limitations in response to a bronchodilator is an …

Recent reports suggest that β 2-adrenergic receptor (ADRB2) genotypes are associated with
therapeutic responses to β 2 agonists in asthmatics. However, few studies have investigated …

BACKGROUND: Chronic obstructive pulmonary disease (COPD) is a heterogeneous
disease that is characterized by varying degrees of involvement of airway and lung …

Abstract Introduction Beta‐2‐adrenergic receptor (ADRB2) is present in the cells of the
respiratory tract, including bronchial smooth muscle cells and bronchial epithelium, and is a …

Genetic variation in the ADRB2 gene has been hypothesized to have a role in differential
response to beta-agonist (BA) therapy in asthma. However, study results have been …

The β2-adrenergic receptor (ADRB2) is an important regulator of airway smooth muscle
tone. We tested the hypothesis that three functional polymorphisms in the ADRB2 gene …