A nattokinase carrier bonding with polyglutamic acid peptide dendrimer for improved thrombolysis

M Huang, S Lü, Y Ji, Z Wang, SF Zhang… - Polymers for …, 2019 - Wiley Online Library
Thrombosis has become one of the major diseases harmful to human health. The new‐
generation thrombolytic drug nattokinase (NK) has been used in the treatment of thrombosis …

Synthesis of PEGylated polyglutamic acid peptide dendrimer and its application in dissolving thrombus

SF Zhang, C Gao, S Lü, J He, M Liu, C Wu, Y Liu… - Colloids and Surfaces B …, 2017 - Elsevier
Nattokinase (NK) has been used as a new generation thrombolytic drug, due to its high
safety, low cost and low side effects. However, it is sensitive to external environment and …

Construction of polylysine dendrimer nanocomposites carrying nattokinase and their application in thrombolysis

C Wu, C Gao, S Lü, X Xu, N Wen… - Journal of Biomedical …, 2018 - Wiley Online Library
Thrombotic disease has become one of the leading causes of mortality among humans
globally. Nattokinase (NK), a novel thrombolytic agent, has attracted the attention of …

Multiarm‐polyethylene glycol‐polyglutamic acid peptide dendrimer: design, synthesis, and dissolving thrombus

SF Zhang, S Lü, C Gao, J Yang, X Yan… - … Research Part A, 2018 - Wiley Online Library
Thrombotic events affect many individuals in a number of ways, all of which can cause
significant morbidity and mortality. Nattokinase (NK), as a novel thrombolytic drug, has been …

Synthesis of mesoporous silica/polyglutamic acid peptide dendrimer with dual targeting and its application in dissolving thrombus

M Huang, SF Zhang, S Lü, T Qi, J Yan… - … Research Part A, 2019 - Wiley Online Library
With the frequent occurrence of thrombus diseases, thrombus has become a factor
endangering human health. Nattokinase (NK) is a new generation of thrombolytic drug with …

Non-covalent modification of thrombolytic agent nattokinase: simultaneous improvement of fibrinolysis activity and enzymatic stability

C Chen, H Duan, C Gao, M Liu, Y Wei, X Zhang, Z Liu - RSC Advances, 2014 - pubs.rsc.org
Cardiovascular disease (CVD) has become the leading cause of death globally. Nattokinase
(NK), as a novel thrombolytic agent, has gained more and more attention. However, NK is …

Layer-by-layer self-assembly embedding of nattokinase in chitosan/γ-polyglutamic acid: Preparation, fibrinolytic activity, stability, and in vitro digestion study

Z Liu, Y He, H Zhang, X Ma - European Journal of Pharmaceutics and …, 2024 - Elsevier
Nattokinase (NK) is a thrombolytic enzyme extracted from natto, which can be used to
prevent and treat blood clots. However, it is sensitive to the environment, especially the …

Synthesis of sustained release/controlled release nanoparticles carrying nattokinase and their application in thrombolysis

S Liu, J Zhu, C Liu, J Li, Z Li, J Zhao… - Die Pharmazie-An …, 2021 - ingentaconnect.com
Thrombus-related diseases have a high mortality rate and are seriously threatening human
life and health. Nattokinase (NK), which has a strong thrombolytic effect, can treat thrombotic …

Improvement of the fibrinolytic activity, acid resistance and thermostability of nattokinase by surface charge engineering

Y Li, X Tang, L Chen, A Ma, W Zhu, W Huang… - International Journal of …, 2023 - Elsevier
Nattokinase is a promising thrombolytic drug due to its powerful fibrinolytic effect and few
side effects. However, the low fibrinolytic activity and stability of nattokinase have limited its …

Downstream processing, formulation development and antithrombotic evaluation of microbial nattokinase

R Kapoor, H Harde, S Jain, AK Panda… - Journal of Biomedical …, 2015 - ingentaconnect.com
The present research work describes the downstreaming of nattokinase (NK) produced by
Bacillus subtilis under solid state fermentation; and the role of efficient oral formulation of …