The liver has a key role in the metabolism (ie, inactivation or activation) of many commonly
used anticancer agents—cytotoxics or new biological agents. Therefore, assessment of liver …

The liver is fundamentally important in drug metabolism. In oncology, the astute clinician
must not only understand the meaning and limitations of commonly ordered liver …

Renal or hepatic impairment is a common comorbidity for patients with cancer either
because of the disease itself, toxicity of previous anticancer treatments, or because of other …

The difficult problem faced by multiple generation of practicing physicians is determining the
cause of abnormal liver function tests in cancer patients on chemotherapy. Hepatotoxicity …

After assessment of tumor histology, the next important factor to consider in the selection of a
chemotherapy regime is organ function. Patients who are to receive chemotherapy require …

The liver is the largest parenchymatous organ of the body and central for intermediate
metabolism. Its close contact to the portal blood streaming back from the gut and the …

6051 Background: Patients with HD may require drug dose modification based on the
severity of HD. HD is often assessed using CP criteria, the use of which is advocated by the …

The newer chemotherapy agents have revolutionized the treatment options for a wide
variety of cancers. Most hepatotoxicity from chemotherapeutic drugs is idiosyncratic …

International Liver Cancer Association (ILCA) White Paper on Biomarker Development for
Hepatocellular Carcinoma Page 1 1 International Liver Cancer Association (ILCA) White Paper …

This report reviews published information on the clinical pharmacokinetics of antitumour
agents in patients with liver dysfunction, associated with primary liver disease or liver …