Background Hepatitis C virus infectivity and replication efficiency appears to be dependent
on the lipid content and organization of the plasma membrane of the host cell, as well as of …

BACKGROUND: While involvement of ABCB1 is well known in drug transport, its metabolite
transport role is not so well understood. Like other ABC transporters, ABCB1 might be …

Purpose: To determine the frequencies of important allelic variants and their haplotype
frequencies of the gene among Jordanian population and to compare findings with those …

Chronic hepatitis C (CHC) progression is highly variable and can be influenced by lipid
metabolism. The ATP-binding cassette transporter A1 (ABCA1) is involved in lipid …

The outcome of hepatitis C virus (HCV) infection and the likelihood of a sustained virological
response (SVR) to antiviral therapy depends on both viral and host characteristics. In vitro …

Chronic HCV (hepatitis C virus)-associated cirrhosis represents a major indication for liver
transplantation. Bile acids contribute to hepatic stellate cell activation as a key event in …

Background ABCB1, also known as P-glycoprotein (P-gp), is the most well studied member
of the ATP-binding cassette (ABC) family of transporters. ABCB1 is embedded in the lumen …

The ATP‐binding cassette (ABC) transporter ABCB1, or P‐glycoprotein, is a transmembrane
efflux pump well known for its implication in drug transport and chemoresistance. ABCB1 …

Background: ATP-binding cassette transporter 1 (ABCB1) plays a critical role in the
development and progression of cardiovascular disease. Emerging evidence suggests that …

The gene product ABCB1 (formerly MDR1 or P-glycoprotein) is hypothesized to be involved
in cholesterol cellular trafficking, redistribution and intestinal re-absorption. Carriers of the …