Background Platelets are small anucleate cells that circulate in the blood in a resting state
but can be activated by external cues. In case of need, platelets from blood donors can be …

Megakaryocytes (MKs) are rare hematopoietic cells in the adult bone marrow and produce
platelets that are critical to vascular hemostasis and wound healing. Ex vivo generation of …

The process of hemostasis and blood coagulation relies heavily on a sufficient supply of
platelets (PLTs, also known as thrombocytes) within a person's bloodstream. Platelet …

Abstract MRG-1 Human induced pluripotent stem cells (hiPSCs) are a promising source of
blood cells, including platelets, for transfusion. However, there remains a need for: 1) a …

Human pluripotent stem cells and in particular induced pluripotent stem cells (iPSC) derived
from adult tissue have recently opened novel and promising avenues for cell therapy. In vitro …

Several protocols exist for generating megakaryocytes (MKs) and platelets from human
induced pluripotent stem cells (hiPSCs) with limited efficiency. We observed previously that …

As a standard clinical treatment, platelet transfusion has been employed to prevent
hemorrhage in patients with thrombocytopenia or platelet dysfunctions. Platelets also show …

Platelet deficiency, known as thrombocytopenia, can cause haemorrhage and is treated with
platelet transfusions. We developed a system for the production of platelet precursor cells …

There exists a need to produce platelets in vitro for use in transfusion medicine, due to
increased platelet demands and short shelf life. Our lab uses human induced pluripotent …

Human embryonic stem cells (hESCs) represent a potential source of blood cells for
transfusion therapies and a promising tool for studying the ontogeny of hematopoiesis …