Human pluripotent stem cells [PSCs; including human embryonic stem cells (ESCs) and
induced pluripotent stem cells (iPSCs)] can infinitely proliferate in vitro and are easily …

Platelet deficiency, known as thrombocytopenia, can cause hemorrhage and is treated with
platelet transfusions. We developed a system for the production of platelet precursor cells …

Human (h) induced pluripotent stem cells (iPSCs) are a potentially abundant source of blood
cells, but how best to select iPSC clones suitable for this purpose from among the many …

Human pluripotent stem cells (hPSC) have the potential to produce any tissue type in the
body and thus represent a source of cells for regenerative medicine. Here we have shown …

The differentiation of megakaryocytes from human pluripotent stem cells in vitro offers
intriguing new perspectives for research and transfusion medicine. However, applications …

The donor-dependent supply of platelets is frequently insufficient to meet transfusion needs.
To address this issue, we developed a clinically applicable strategy for the derivation of …

The production of megakaryocytes (MKs)—the precursors of blood platelets—from human
pluripotent stem cells (hPSCs) offers exciting clinical opportunities for transfusion medicine …

The contents of platelet α‐granules arrive via a number of pathways; some are synthesized
by megakaryocytes (MKs), for example, von Willebrand factor (VWF), whereas others are …

Abstract Abstract 2540 Poster Board II-517 Platelets collected from donors have very limited
shelf life and are increasingly needed for transfusions. In contrast to donor dependent cord …