The Pitx2 gene encodes a homeobox transcription factor that is required for mammalian
development. Disruption of PITX2 expression in humans causes congenital heart diseases …

Cardiac development is a complex morphogenetic process initiated as bilateral cardiogenic
mesoderm is specified at both sides of the gastrulating embryo. Soon thereafter, these …

Pitx2 is a homeobox transcription factor involved in left–right signaling during
embryogenesis. Disruption of left–right signaling in mice within its core nodal/lefty cascade …

The homeobox transcription factor Pitx2 displays a highly specific expression pattern during
embryogenesis. Gain and loss of function experiments have unraveled its pivotal role in left …

Background—Pitx2 is a homeobox transcription factor that plays a pivotal role in early
left/right determination during embryonic development. Pitx2 loss-of-function mouse mutants …

Aim: The knowledge of the molecular signals that control cell differentiation into
cardiomyocytes is critical to apply cell-based therapies and repair an injured heart. The …

The Pitx2 gene regulates left-right (L/R) asymmetrical cardiac morphogenesis. Constitutive
Pitx2 knock out (ko) mice die before birth and display, among other defects, right atrial …

The expression of Pitx2 is already confined to the left cardiac crescent at the cardiac
crescent stage (Fig. 1a)(mouse embryonic day [E] E7. 5; chick Hamburger and Hamilton …

Pitx2 is a bicoid-related homeodomain transcription factor that plays a critical role in
directing cardiac asymmetric morphogenesis. Ectopic Pitx2c expression in the developing …

The homeobox gene Pitx2 has been characterized as a mediator of left-right signaling in
heart, gut, and lung morphogenesis. However, the relationship between the developmental …