HLA-A* 02: 07 is a protective allele for EBV negative and a susceptibility allele for EBV positive classical Hodgkin lymphoma in China

X Huang, B Hepkema, I Nolte, K Kushekhar… - PLoS …, 2012 - journals.plos.org
HLA-A2 protects from EBV+ classical Hodgkin lymphoma (cHL) in Western Europe, but it is
unknown whether this protective effect also exists in the Chinese population. We …

HLA expression and HLA type associations in relation to EBV status in Hispanic Hodgkin lymphoma patients

LB Fletcher, RN Veenstra, EY Loo, AE Hwang… - PLoS …, 2017 - journals.plos.org
A proportion of classical Hodgkin lymphomas harbor the Epstein Barr virus (EBV). We
previously demonstrated that associations between Human Leukocyte Antigen (HLA) alleles …

HLA associations in classical Hodgkin lymphoma: EBV status matters

X Huang, K Kushekhar, I Nolte, W Kooistra, L Visser… - PloS one, 2012 - journals.plos.org
The pathogenesis of classical Hodgkin lymphoma (cHL) involves environmental and genetic
factors. To explore the role of the human leukocyte antigen (HLA) genes, we performed a …

HLA-A*02 is associated with a reduced risk and HLA-A*01 with an increased risk of developing EBV+ Hodgkin lymphoma

M Niens, RF Jarrett, B Hepkema… - Blood, The Journal …, 2007 - ashpublications.org
Previous studies showed that the HLA class I region is associated with Epstein-Barr virus
(EBV)–positive Hodgkin lymphoma (HL) and that HLA-A is the most likely candidate gene in …

HLA Allele E*01:01 Is Associated with a Reduced Risk of EBV-Related Classical Hodgkin Lymphoma Independently of HLA-A*01/*02

P Martín, I Krsnik, B Navarro, M Provencio, JF García… - PLoS …, 2015 - journals.plos.org
Background An inefficient immune response against Epstein-Barr virus (EBV) infection is
related to the pathogenesis of a subgroup of classical Hodgkin lymphomas (cHL). Some …

HLA-A alleles and infectious mononucleosis suggest a critical role for cytotoxic T-cell response in EBV-related Hodgkin lymphoma

H Hjalgrim, K Rostgaard… - Proceedings of the …, 2010 - National Acad Sciences
A proportion of classical Hodgkin lymphoma (HL) is believed to be causally related to
infection with the ubiquitous lymphotropic EBV. The determining factors for development of …

Expression of HLA class I and HLA class II by tumor cells in Chinese classical Hodgkin lymphoma patients

X Huang, A van den Berg, Z Gao, L Visser, I Nolte… - PLoS …, 2010 - journals.plos.org
Background In Caucasian populations, the tumor cells of Epstein Barr virus (EBV)-positive
classical Hodgkin Lymphomas (cHL) patients more frequently express HLA class I and HLA …

The impact of HLA class I and EBV latency-II antigen-specific CD8+ T cells on the pathogenesis of EBV+ Hodgkin lymphoma

K Jones, L Wockner, RM Brennan… - Clinical & …, 2016 - academic.oup.com
In 40% of cases of classical Hodgkin lymphoma (cHL), Epstein–Barr virus (EBV) latency-II
antigens [EBV nuclear antigen 1 (EBNA1)/latent membrane protein (LMP) 1/LMP2A] are …

Modeling HLA associations with EBV‐positive and‐negative H odgkin lymphoma suggests distinct mechanisms in disease pathogenesis

PCD Johnson, KA McAulay… - … Journal of Cancer, 2015 - Wiley Online Library
HLA genotyping and genome wide association studies provide strong evidence for
associations between Human Leukocyte Antigen (HLA) alleles and classical Hodgkin …

The Association of HLA‐Class I and Class II with Hodgkin's Lymphoma in Iranian Patients

A Sayad, MT Akbari, M Mehdizadeh… - BioMed research …, 2014 - Wiley Online Library
The Hodgkin's lymphoma disease (HD) is a common malignant neoplasm with germinal
centre B‐cell origin. It has been suggested that the HLA class I and class II regions have …