Clinical islet transplantation is a successful procedure that can improve the quality of life in
recipients with diabetes. A drawback of the procedure is the need for chronic administration …

Islet transplantation has great potential for curing type 1 diabetes; however, long-term islet
survival using conventional immunosuppression remains elusive. We present a novel …

Background. Successful islet transplantation in type 1 diabetes requires tolerance induction
of both allo-and autoreactive T-cell responses. Monoclonal antibodies targeting the CD4 …

Background. Pancreatic islet transplantation can correct the disordered glucose metabolism
of type 1 diabetes, but the number of successful transplants has been low because of the …

While great advances have been made in the success of islet transplantation to cure
autoimmune diabetes, this protocol remains limited by our inability to induce donor‐specific …

Allorejection and recurrence of autoimmunity are the major barriers to transplantation of
islets of Langerhans for the cure of type 1 diabetes in humans. CD40-CD154 (CD40 ligand) …

We studied the effects of anti-CD4 treatment of diabetic ACI rats on the induction oftolerance
to allogeneic (Lewis) islet allografts. When given as a 4-day treatment regimen, OX38, a …

Once nonobese diabetic (NOD) mice become diabetic, they are highly resistant to islet
transplantation. The precise mechanism of such resistance remains largely unknown. In the …

Background. T-cell activation and the subsequent induction of effector functions require not
only the recognition of antigen peptides bound to MHC molecules by T-cell receptor (TCR) …

Background. Although islet cell transplantation is considered an ideal form of endocrine
replacement for type I diabetes, clinical application in humans is still not feasible. New …