The posterior cingulate cortex, a key hub of the default mode network, underlies
autobiographical memory retrieval and displays hypometabolic changes early in Alzheimer …

The posterior cingulate cortex (PCC) is a key hub of the default mode network underlying
autobiographical memory retrieval, which falters early in the progression of Alzheimer's …

While the concept of cognitive resilience is well-established it has not been defined in a way
that can be measured. This has been an impediment to studying its underlying biology and …

We initiated the systematic profiling of the dorsolateral prefrontal cortex obtained from a
subset of autopsied individuals enrolled in the Religious Orders Study (ROS) or the Rush …

Although neuritic plaques and neurofibrillary tangles in older adults are correlated with
cognitive impairment and severity of dementia, it has long been recognized that the …

Summary Alzheimer's disease (AD), the leading cause of dementia, affects millions of
people worldwide. With no disease-modifying medication currently available, the human toll …

With the expected rise in Alzheimer's disease and related dementias (ADRD) in the coming
decades due to the aging population and a lack of effective disease-modifying treatments …

Introduction It remains unclear why age increases risk of Alzheimer's disease and why some
people experience age‐related cognitive decline in the absence of dementia. Here we test …

The posterior cingulate cortex (PCC) is a key hub of the default mode network, a resting-
state network involved in episodic memory, showing functional connectivity (FC) changes in …

Importance Identifying genes and proteins for cognitive resilience (ie, targets that may be
associated with slowing or preventing cognitive decline regardless of the presence, number …