Abstract Roquin-1 (Rc3h1) is an E3 ubiquitin ligase originally discovered in a mutational
screen for genetic factors contributory to systemic lupus erythematosus-like symptoms in …

The T-cell receptor (TCR) engages with an antigen and initiates a signaling cascade that
leads to the activation of transcription factors. Roquin, a protein encoded by the RC3H1 …

ROQUIN is an RNA‐binding protein that plays important roles in both the innate and
adaptive immune systems. ROQUIN binds to several key immune‐relevant messenger RNA …

Roquin, an E3 ligase, is involved in curtailing autoimmune pathology as seen from studies
using mice with mutated (Rc3h1 san/san) or disrupted (Rc3h1 gt/gt) Rc3h1 gene. The extent …

Hyperinflammatory syndromes are life-threatening disorders caused by overzealous
immune cell activation and cytokine release, often resulting from defects in negative …

Accumulation of T follicular helper (Tfh) cells and proinflammatory cytokines drive
autoantibody-mediated diseases. The RNA-binding protein Roquin-1 (Rc3h1) represses the …

Roquin-1, a RING finger E3 ubiquitin ligase, functions as a modulator of inflammation;
however, nothing is known about how Rc3h1 expression is regulated. Here, we describe an …

Roquins are a family of highly conserved RNA-binding proteins that also contain a RING-
type E3 ubiquitin ligase domain. They repress constitutive decay elements containing …

Post-transcriptional gene regulation controls the amount of protein produced from a specific
mRNA by altering both its decay and translation rates. Such regulation is primarily achieved …

Post‐transcriptional gene regulation by RNA‐binding proteins is a fast and effective way to
adapt gene expression and change cellular responses. These trans‐acting factors have …