[HTML][HTML] Polygenic risk score for genetic evaluation of prostate cancer risk in Asian populations: A narrative review

SH Song, SS Byun - Investigative and clinical urology, 2021 - ncbi.nlm.nih.gov
Decreasing costs of genetic testing and interest in disease inheritance has changed the
landscape of cancer prediction in prostate cancer (PCa), and guidelines now include …

Application of European‐specific polygenic risk scores for predicting prostate cancer risk in different ancestry populations

X Ruan, D Huang, J Huang, D Xu, R Na - The Prostate, 2023 - Wiley Online Library
Background Polygenic risk score (PRS) has shown promise in predicting prostate cancer
(PCa) risk. However, the application of PRS in non‐European ancestry was poorly studied …

Clinical validity and utility of genetic risk scores in prostate cancer

BT Helfand, J Kearns, C Conran, J Xu - Asian journal of andrology, 2016 - journals.lww.com
Current issues related to prostate cancer (PCa) clinical care (eg, over-screening, over-
diagnosis, and over-treatment of nonaggressive PCa) call for risk assessment tools that can …

[HTML][HTML] How Well do Polygenic Risk Scores Identify Men at High Risk for Prostate Cancer? Systematic Review and Meta-Analysis

A Siltari, R Lönnerbro, K Pang, K Shiranov… - Clinical genitourinary …, 2023 - Elsevier
Objectives Genome-wide association studies have revealed over 200 genetic susceptibility
loci for prostate cancer (PCa). By combining them, polygenic risk scores (PRS) can be …

[HTML][HTML] Evaluation of polygenic risk scores for prediction of prostate cancer in Korean men

JJ Oh, E Kim, E Woo, SH Song, JK Kim, H Lee… - Frontiers in …, 2020 - frontiersin.org
Aims The purpose of this study is to evaluate an aggregate influence of prostate cancer
(PCa) susceptibility variants on the development of PCa in Korean men by using the …

[HTML][HTML] Genetic score is an objective and better measurement of inherited risk of prostate cancer than family history

J Sun, R Na, FC Hsu, SL Zheng, F Wiklund… - European …, 2013 - ncbi.nlm.nih.gov
Positive family history of prostate cancer (PCa) has been consistently associated with
increased PCa risk [1]. It is widely used in clinical practice and is a strong indication …

Predictive performance of prostate cancer risk in Chinese men using 33 reported prostate cancer risk‐associated SNPs

J Zheng, F Liu, X Lin, X Wang, Q Ding, H Jiang… - The …, 2012 - Wiley Online Library
BACKGROUND Genome‐wide association studies (GWAS) have identified more than 30
single nucleotide polymorphisms (SNPs) that were reproducibly associated with prostate …

[HTML][HTML] Prediction of clinically significant prostate cancer using polygenic risk models in Asians

SH Song, E Kim, E Woo, E Kwon, S Yoon… - … and clinical urology, 2022 - ncbi.nlm.nih.gov
Purpose To develop and evaluate the performance of a polygenic risk score (PRS)
constructed in a Korean male population to predict clinically significant prostate cancer …

[HTML][HTML] Prostate cancer risk-associated genetic markers and their potential clinical utility

J Xu, J Sun, SL Zheng - Asian journal of andrology, 2013 - ncbi.nlm.nih.gov
Prostate cancer (PCa) is one of the most common cancers among men in Western
developed countries and its incidence has increased considerably in many other parts of the …

Validation of a prostate cancer polygenic risk score

MH Black, S Li, H LaDuca, MT Lo, J Chen… - The …, 2020 - Wiley Online Library
Background Genome‐wide association studies have identified over 100 single‐nucleotide
polymorphisms (SNPs) associated with prostate cancer (PrCa), and polygenic risk scores …