Background Genome‐wide association studies have identified over 100 single‐nucleotide
polymorphisms (SNPs) associated with prostate cancer (PrCa), and polygenic risk scores …

Genome-wide polygenic risk scores (GW-PRSs) have been reported to have better
predictive ability than PRSs based on genome-wide significance thresholds across …

Background: Genome-wide association studies have identified multiple genetic variants
associated with prostate cancer risk which explain a substantial proportion of familial relative …

Background Single nucleotide polymorphism–based genetic risk score (GRS) has been
developed and validated for prostate cancer (PCa) risk assessment. As GRS is population …

Polygenic risk scores for prostate cancer: testing considerations Page 1 © The Canadian
Journal of UrologyTM: International Supplement, October 2019 Polygenic risk scores for …

Background Genetic factors play an important role in prostate cancer (PCa) susceptibility.
Objective To discover common genetic variants contributing to the risk of PCa in men of …

Hereditary factors have a strong influence on prostate cancer (PC) risk and poorer
outcomes, thus stratification by genetic factors addresses a critical need for targeted PC …

BACKGROUND Polygenic risk scores comprising established susceptibility variants have
shown to be informative classifiers for several complex diseases including prostate cancer …

Prostate cancer (PCa) testing is recommended by most authoritative groups for high-risk
men including those with a family history of the disease. However, family history information …

Several different approaches are available to clinicians for determining prostate cancer
(PCa) risk. The clinical validity of various PCa risk assessment methods utilizing single …