Rationale: Kidney homeostasis is critically determined by the coordinated activity of the
renin-angiotensin system (RAS), including the balanced synthesis of its main effector …

Cardiovascular and renal pathologies are frequently associated with an activated renin-
angiotensin-system (RAS) and increased levels of its main effector and vasoconstrictor …

Alteration in renin‐angiotensin system (RAS) has been implicated in the pathophysiology of
diabetic kidney disease (DKD). The deleterious actions of angiotensin II (Ang II) could be …

Arterial hypertension is the most prevalent chronic disease in the adult population of
developed countries and it constitutes a significant risk factor in the development of …

Despite current practice, patients with chronic kidney disease (CKD) are at increased risk of
progression to end-stage renal disease and cardiovascular events. Neprilysin inhibition …

BACKGROUND Neprilysin (NEP) is a membrane-bound neutral endopeptidase that
degrades a variety of bioactive peptides. The substrates include natriuretic peptides (NPs) …

Background Since the introduction of sacubitril/valsartan in clinical cardiology, neprilysin
has become a major target for heart failure treatment. Plasma neprilysin concentration has …

The potential role of soluble neprilysin (sNEP) as a biomarker has been poorly documented.
Hence, the present systematic review emphasizes to explore sNEP as an emerging …

Sacubitril/valsartan is one of a new line of therapeutic agents for patients with heart failure.
Given the relationships between kidney disease and structural heart disease, testing the …

Bradykinin has important physiological actions related to the regulation of blood vessel tone
and renal function, and protection from ischemia reperfusion injury. However, bradykinin …