Loss of the Two-Component System TctD-TctE in Pseudomonas aeruginosa Affects Biofilm Formation and Aminoglycoside Susceptibility in Response to Citric Acid

PK Taylor, L Zhang, TF Mah - Msphere, 2019 - Am Soc Microbiol
The two-component system TctD-TctE is important for regulating the uptake of tricarboxylic
acids in Pseudomonas aeruginosa. TctD-TctE accomplishes this through derepression of …

Redundancy in Citrate and cis-Aconitate Transport in Pseudomonas aeruginosa

SAM Underhill, MT Cabeen - Journal of Bacteriology, 2022 - Am Soc Microbiol
Tricarboxylates such as citrate are the preferred carbon sources for Pseudomonas
aeruginosa, an opportunistic pathogen that causes chronic human infections. However, the …

Roles of two-component regulatory systems in antibiotic resistance

ARP Tierney, PN Rather - Future microbiology, 2019 - Future Medicine
Two-component regulatory systems (TCSs) are a major mechanism by which bacteria sense
and respond to changes in their environment. TCSs typically consist of two proteins that …

Role of Two-Component System Networks in Pseudomonas aeruginosa Pathogenesis

V Ducret, K Perron, M Valentini - Pseudomonas aeruginosa: Biology …, 2022 - Springer
Two-component systems (TCS) are the largest family of signaling systems in the bacterial
kingdom. They enable bacteria to cope with a wide range of environmental conditions via …

A Stenotrophomonas maltophilia TetR-like transcriptional regulator involved in fatty acid metabolism is controlled by quorum sensing signals

X Coves, M Bravo, P Huedo… - Applied and …, 2023 - Am Soc Microbiol
Stenotrophomonas maltophilia is an environmental bacterium as well as an emerging
opportunistic multidrug-resistant pathogen. They use the endogenous diffusible signal factor …

Pseudomonas aeruginosa citrate synthase GltA influences antibiotic tolerance and the type III secretion system through the stringent response

H Chen, X Gong, Z Fan, Y Xia, Y Jin, F Bai… - Microbiology …, 2023 - Am Soc Microbiol
Carbohydrate metabolism plays essential roles in energy generation and providing carbon
skeletons for amino acid syntheses. In addition, carbohydrate metabolism has been shown …

The Roles of the Two-Component System, MtrAB, in Response to Diverse Cell Envelope Stresses in Dietzia sp. DQ12-45-1b

X Qin, K Zhang, Y Nie, XL Wu - Applied and Environmental …, 2022 - Am Soc Microbiol
Two-component systems (TCSs) act as common regulatory systems allowing bacteria to
detect and respond to multiple environmental stimuli, including cell envelope stress. The …

Roles of Two-Component Systems in Pseudomonas aeruginosa Virulence

M Sultan, R Arya, KK Kim - International journal of molecular sciences, 2021 - mdpi.com
Pseudomonas aeruginosa is an opportunistic pathogen that synthesizes and secretes a
wide range of virulence factors. P. aeruginosa poses a potential threat to human health …

PA3225 is a transcriptional repressor of antibiotic resistance mechanisms in Pseudomonas aeruginosa

CW Hall, L Zhang, TF Mah - Antimicrobial Agents and …, 2017 - Am Soc Microbiol
The tssABC1 locus is part of the Hcp secretion island I (HSI-I) type VI secretion system
(T6SS) in Pseudomonas aeruginosa. Previous work implicated the tssC1 gene in P …

[PDF][PDF] Pseudomonas aeruginosa utilizes host-derived itaconate to redirect its metabolism to promote biofilm formation

SA Riquelme, K Liimatta, TWF Lung, B Fields, D Ahn… - Cell metabolism, 2020 - cell.com
The bacterium Pseudomonas aeruginosa is especially pathogenic, often being associated
with intractable pneumonia and high mortality. How P. aeruginosa avoids immune clearance …