Precise staging of beetle horn formation in Trypoxylus dichotomus reveals the pleiotropic roles of doublesex depending on the spatiotemporal developmental …

S Morita, T Ando, A Maeno, T Mizutani, M Mase… - PLoS …, 2019 - journals.plos.org
Many scarab beetles have sexually dimorphic exaggerated horns that are an evolutionary
novelty. Since the shape, number, size, and location of horns are highly diverged within …

The role of doublesex in the evolution of exaggerated horns in the Japanese rhinoceros beetle

Y Ito, A Harigai, M Nakata, T Hosoya, K Araya… - EMBO …, 2013 - embopress.org
Male‐specific exaggerated horns are an evolutionary novelty and have diverged rapidly via
intrasexual selection. Here, we investigated the function of the conserved sex‐determination …

Asymmetric interactions between doublesex and tissue- and sex-specific target genes mediate sexual dimorphism in beetles

CC Ledón-Rettig, EE Zattara, AP Moczek - Nature Communications, 2017 - nature.com
Sexual dimorphisms fuel significant intraspecific variation and evolutionary diversification.
Yet the developmental-genetic mechanisms underlying sex-specific development remain …

Diversification of doublesex function underlies morph-, sex-, and species-specific development of beetle horns

T Kijimoto, AP Moczek… - Proceedings of the …, 2012 - National Acad Sciences
Sex-specific trait expression is frequently associated with highly variable, condition-
dependent expression within sexes and rapid divergence among closely related species …

Evolutionary transition of doublesex regulation from sex-specific splicing to male-specific transcription in termites

S Miyazaki, K Fujiwara, K Kai, Y Masuoka, H Gotoh… - Scientific reports, 2021 - nature.com
The sex determination gene doublesex (dsx) encodes a transcription factor with two
domains, oligomerization domain 1 (OD1) and OD2, and is present throughout insects. Sex …

The draft genome sequence of the Japanese rhinoceros beetle Trypoxylus dichotomus septentrionalis towards an understanding of horn formation

S Morita, TF Shibata, T Nishiyama, Y Kobayashi… - Scientific Reports, 2023 - nature.com
Abstract The Japanese rhinoceros beetle Trypoxylus dichotomus is a giant beetle with
distinctive exaggerated horns present on the head and prothoracic regions of the male. T …

Sex determination in beetles: Production of all male progeny by Parental RNAi knockdown of transformer

JN Shukla, SR Palli - Scientific reports, 2012 - nature.com
Sex in insects is determined by a cascade of regulators ultimately controlling sex-specific
splicing of a transcription factor, Doublesex (Dsx). We recently identified homolog of dsx in …

Candidate target genes of the male-specific expressed Doublesex in the termite Reticulitermes speratus

K Fujiwara, S Miyazaki, K Maekawa - Plos one, 2024 - journals.plos.org
Eusocial insects such as termites, ants, bees, and wasps exhibit a reproductive division of
labor. The developmental regulation of reproductive organ (ovaries and testes) is crucial for …

Pupal remodeling and the development and evolution of sexual dimorphism in horned beetles

AP Moczek - The American Naturalist, 2006 - journals.uchicago.edu
Horns or hornlike structures in beetles have become an increasingly popular study system
for exploring the evolution and development of secondary sexual trait diversity and sexual …

Hemimetabolous insects elucidate the origin of sexual development via alternative splicing

J Wexler, EK Delaney, X Belles, C Schal… - Elife, 2019 - elifesciences.org
Insects are the only known animals in which sexual differentiation is controlled by sex-
specific splicing. The doublesex transcription factor produces distinct male and female …