Mitochondrial dysfunction is implicated in the pathogenesis of Alzheimer's disease (AD).
However, the precise mitochondrial molecular deficits in AD remain poorly understood …

Alzheimer's disease (AD) is the most common age-associated dementia with complex
pathological hallmarks. Mitochondrion, synaptosome, and myelin sheath appear to be …

The Tg2576 mouse, which carries the Swedish mutant form of human β-amyloid precursor
protein (hAPPswe), develops Alzheimer's Disease (AD)-like phenotype (synaptic pathology …

Many neurodegenerative disorders, including Alzheimer's disease (AD), are strongly
associated with the accumulation of oxidative damage. Transgenic animal models are …

The molecular mechanisms underlying cognitive impairment in Alzheimer's disease (AD)
remain largely unclear. In the present study, we were aimed to identify the potential key …

Alzheimer's disease (AD) is one of the most common progressive neurodegenerative
diseases. Apolipoprotein E4 (ApoE4) carriers account for 40% of all AD cases, emphasizing …

Alzheimer's disease (AD) is the most common neurodegenerative disorder worldwide.
Mitochondrial dysfunction is thought to be an early event in the onset and progression of AD; …

Mitochondrial structural and functional alterations appear to play to an important role in the
pathogenesis of Alzheimer's disease (AD). In the present study, we used a quantitative …

Synaptic aging has been associated with neuronal circuit dysfunction and cognitive decline.
Reduced mitochondrial function may be an early event that compromises synaptic integrity …

Introduction Accumulation of β-amyloid (Aβ) in neurons of patients with Alzheimer's disease
(AD) inhibits the activity of key enzymes in mitochondrial metabolic pathways, triggering …