Characterization of Novel Anti-VEGFR Antibodies to Develop Agonists Targeting Mesoderm Differentiation

S Mishra - 2021 - search.proquest.com
Novel antibodies against VEGF receptors were produced and characterized to develop
agonists for targeted mesoderm differentiation. A major drawback underlying mesoderm …

Inhibition of angiogenesis by a novel neutralizing antibody targeting human VEGFR-3

H Chen, X Ding, Y Gao, X Jiang, X Liu, Y Chen, J Gao… - MAbs, 2013 - Taylor & Francis
Vascular endothelial growth factor receptor 3 (VEGFR-3) is a receptor for the vascular
endothelial growth factor C and D (VEGF-C and D) and plays a critical role in the …

[HTML][HTML] Expression, purification, and characterization of a diabody against the most important angiogenesis cell receptor: vascular endothelial growth factor receptor 2

M Behdani, S Zeinali, M Karimipour… - Advanced Biomedical …, 2012 - journals.lww.com
Antibodies and their derivative fragments have long been used as tools in a variety of
applications, in fundamental research work, biotechnology, diagnosis, and therapy. Camels …

Vascular Endothelial Growth Factor Receptor Antibodies for Anti-Angiogenic Therapy

P Bohlen, Z Zhu, DJ Hicklin - Tumor Angiogenesis: Basic Mechanisms and …, 2007 - Springer
Vascular endothelial cell growth factors (VEGFs) and their receptors are key molecules in
the development and maintenance of the vascular and lymphatic systems in mammals …

Generation of a mouse monoclonal antibody recognizing both the native and denatured forms of human VEGF

HQ Hu, YN Sun, SP Luo, Q Zhou, FL Tao, Z Chen… - Hybridoma, 2009 - liebertpub.com
Vascular endothelial growth factor (VEGF) and its related member, placental growth factor
(PlGF), play important roles in stimulating vascular growth (angiogenesis) in both …

[HTML][HTML] Human recombinant VEGFR2D4 biochemical characterization to investigate novel anti-VEGFR2D4 antibodies for allosteric targeting of VEGFR2

R Di Stasi, L De Rosa, D Diana, R Fattorusso… - Molecular …, 2019 - Springer
Abstract VEGF-A/VEGFR2 complex is the major signaling pathway involved in angiogenesis
and the inhibition of this axis retards tumor growth and inflammatory disorders progression …

Cross-species vascular endothelial growth factor (VEGF)-blocking antibodies completely inhibit the growth of human tumor xenografts and measure the contribution of …

WC Liang, X Wu, FV Peale, CV Lee, YG Meng… - Journal of Biological …, 2006 - ASBMB
To fully assess the role of VEGF-A in tumor angiogenesis, antibodies that can block all
sources of vascular endothelial growth factor (VEGF) are desired. Selectively targeting tumor …

Engineering surfaces for site-specific vascular differentiation of mouse embryonic stem cells

CK Chiang, MF Chowdhury, RK Iyer, WL Stanford… - Acta biomaterialia, 2010 - Elsevier
Differentiation of stem and progenitor cells routinely relies on the application of soluble
growth factors, an approach that enables temporal control of cell fate but enables no spatial …

VEGFR2-PLCγ1 axis is essential for endothelial specification of VEGFR2+ vascular progenitor cells

H Sase, T Watabe, K Kawasaki… - Journal of cell …, 2009 - journals.biologists.com
Vascular endothelial growth factor receptor 2 (VEGFR2) plays crucial roles in
vasculogenesis, a process involving cell proliferation, migration and differentiation …

The VEGF family in cancer and antibody-based strategies for their inhibition

LA Sullivan, RA Brekken - MAbs, 2010 - Taylor & Francis
Angiogenesis is required in normal physiological processes, but is also involved in tumor
growth, progression and metastasis. Vascular endothelial growth factor (VEGF), a primary …