Myeloid C/EBPβ deficiency reshapes microglial gene expression and is protective in experimental autoimmune encephalomyelitis

M Pulido-Salgado, JM Vidal-Taboada… - Journal of …, 2017 - Springer
Background CCAAT/enhancer binding protein β (C/EBPβ) is a transcription factor that
regulates the expression of important pro-inflammatory genes in microglia. Mice deficient for …

Pro-inflammatory gene expression and neurotoxic effects of activated microglia are attenuated by absence of CCAAT/enhancer binding protein β

M Straccia, N Gresa-Arribas, G Dentesano… - Journal of …, 2011 - Springer
Background Microglia and astrocytes respond to homeostatic disturbances with profound
changes of gene expression. This response, known as glial activation or neuroinflammation …

Inhibition of CD200R1 expression by C/EBP beta in reactive microglial cells

G Dentesano, M Straccia, A Ejarque-Ortiz… - Journal of …, 2012 - Springer
Background In physiological conditions, it is postulated that neurons control microglial
reactivity through a series of inhibitory mechanisms, involving either cell contact-dependent …

C/EBPβ regulates multiple IL-1β-induced human astrocyte inflammatory genes

J Fields, A Ghorpade - Journal of neuroinflammation, 2012 - Springer
Background CCAAT enhancer-binding protein (C/EBP) β regulates gene expression in
multiple organ systems and cell types, including astrocytes in the central nervous system …

C/EBPβ and C/EBPδ transcription factors: Basic biology and roles in the CNS

M Pulido-Salgado, JM Vidal-Taboada, J Saura - Progress in Neurobiology, 2015 - Elsevier
CCAAT/enhancer binding protein (C/EBP) β and C/EBPδ are transcription factors of the
basic-leucine zipper class which share phylogenetic, structural and functional features. In …

Upregulation of CCAAT/enhancer binding protein β in activated astrocytes and microglia

A Ejarque‐Ortiz, MG Medina, JM Tusell… - Glia, 2007 - Wiley Online Library
The transcription factor CCAAT/enhancer binding protein β (C/EBPβ) regulates the
expression of key genes in inflammation but little is known about the involvement of C/EBPβ …

CCAAT/enhancer binding protein δ regulates glial proinflammatory gene expression

T Valente, M Straccia, N Gresa-Arribas… - Neurobiology of …, 2013 - Elsevier
The transcription factor CCAAT/enhancer binding protein δ (C/EBPδ) is expressed in
activated astrocytes and microglia and can regulate the expression of potentially detrimental …

Expression of C/EBPα and C/EBPβ in glial cells in vitro after inducing glial activation by different stimuli

K Pérez-Capote, J Saura, J Serratosa, C Solà - Neuroscience letters, 2006 - Elsevier
We studied the involvement of two members of the CCAAT/enhancer binding proteins
(C/EBPs) family of transcription factors, C/EBPα and C/EBPβ, in glial activation induced by …

Decreased brain damage and curtailed inflammation in transcription factor CCAAT/enhancer binding protein β knockout mice following transient focal cerebral …

R Kapadia, K Tureyen, KK Bowen… - Journal of …, 2006 - Wiley Online Library
CCAAT/enhancer binding protein β (C/EBPβ) is a leucine‐zipper transcription factor that
regulates cell growth and differentiation in mammals. Expression of many pro‐inflammatory …

[HTML][HTML] Ubiquitin ligase COP1 suppresses neuroinflammation by degrading c/EBPβ in microglia

A Ndoja, R Reja, SH Lee, JD Webster, H Ngu… - Cell, 2020 - cell.com
Dysregulated microglia are intimately involved in neurodegeneration, including Alzheimer's
disease (AD) pathogenesis, but the mechanisms controlling pathogenic microglial gene …