Myeloid C/EBPβ deficiency reshapes microglial gene expression and is protective in experimental autoimmune encephalomyelitis
M Pulido-Salgado, JM Vidal-Taboada… - Journal of …, 2017 - Springer
Background CCAAT/enhancer binding protein β (C/EBPβ) is a transcription factor that
regulates the expression of important pro-inflammatory genes in microglia. Mice deficient for …
regulates the expression of important pro-inflammatory genes in microglia. Mice deficient for …
Pro-inflammatory gene expression and neurotoxic effects of activated microglia are attenuated by absence of CCAAT/enhancer binding protein β
M Straccia, N Gresa-Arribas, G Dentesano… - Journal of …, 2011 - Springer
Background Microglia and astrocytes respond to homeostatic disturbances with profound
changes of gene expression. This response, known as glial activation or neuroinflammation …
changes of gene expression. This response, known as glial activation or neuroinflammation …
Inhibition of CD200R1 expression by C/EBP beta in reactive microglial cells
G Dentesano, M Straccia, A Ejarque-Ortiz… - Journal of …, 2012 - Springer
Background In physiological conditions, it is postulated that neurons control microglial
reactivity through a series of inhibitory mechanisms, involving either cell contact-dependent …
reactivity through a series of inhibitory mechanisms, involving either cell contact-dependent …
C/EBPβ regulates multiple IL-1β-induced human astrocyte inflammatory genes
J Fields, A Ghorpade - Journal of neuroinflammation, 2012 - Springer
Background CCAAT enhancer-binding protein (C/EBP) β regulates gene expression in
multiple organ systems and cell types, including astrocytes in the central nervous system …
multiple organ systems and cell types, including astrocytes in the central nervous system …
C/EBPβ and C/EBPδ transcription factors: Basic biology and roles in the CNS
M Pulido-Salgado, JM Vidal-Taboada, J Saura - Progress in Neurobiology, 2015 - Elsevier
CCAAT/enhancer binding protein (C/EBP) β and C/EBPδ are transcription factors of the
basic-leucine zipper class which share phylogenetic, structural and functional features. In …
basic-leucine zipper class which share phylogenetic, structural and functional features. In …
Upregulation of CCAAT/enhancer binding protein β in activated astrocytes and microglia
A Ejarque‐Ortiz, MG Medina, JM Tusell… - Glia, 2007 - Wiley Online Library
The transcription factor CCAAT/enhancer binding protein β (C/EBPβ) regulates the
expression of key genes in inflammation but little is known about the involvement of C/EBPβ …
expression of key genes in inflammation but little is known about the involvement of C/EBPβ …
CCAAT/enhancer binding protein δ regulates glial proinflammatory gene expression
T Valente, M Straccia, N Gresa-Arribas… - Neurobiology of …, 2013 - Elsevier
The transcription factor CCAAT/enhancer binding protein δ (C/EBPδ) is expressed in
activated astrocytes and microglia and can regulate the expression of potentially detrimental …
activated astrocytes and microglia and can regulate the expression of potentially detrimental …
Expression of C/EBPα and C/EBPβ in glial cells in vitro after inducing glial activation by different stimuli
K Pérez-Capote, J Saura, J Serratosa, C Solà - Neuroscience letters, 2006 - Elsevier
We studied the involvement of two members of the CCAAT/enhancer binding proteins
(C/EBPs) family of transcription factors, C/EBPα and C/EBPβ, in glial activation induced by …
(C/EBPs) family of transcription factors, C/EBPα and C/EBPβ, in glial activation induced by …
Decreased brain damage and curtailed inflammation in transcription factor CCAAT/enhancer binding protein β knockout mice following transient focal cerebral …
R Kapadia, K Tureyen, KK Bowen… - Journal of …, 2006 - Wiley Online Library
CCAAT/enhancer binding protein β (C/EBPβ) is a leucine‐zipper transcription factor that
regulates cell growth and differentiation in mammals. Expression of many pro‐inflammatory …
regulates cell growth and differentiation in mammals. Expression of many pro‐inflammatory …
[HTML][HTML] Ubiquitin ligase COP1 suppresses neuroinflammation by degrading c/EBPβ in microglia
Dysregulated microglia are intimately involved in neurodegeneration, including Alzheimer's
disease (AD) pathogenesis, but the mechanisms controlling pathogenic microglial gene …
disease (AD) pathogenesis, but the mechanisms controlling pathogenic microglial gene …